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Methamphetamine acts as a powerful central nervous system stimulant.
Methamphetamine acts as a powerful central nervous system stimulant. It is structurally similar to amphetamine but is more potent and has a longer half-life compared to amphetamine. Like many stimulant substances, it causes euphoria (an abnormal state of great happiness, excitement, and well-being), thus leading to strong psychological dependencies. While the effects can vary among users, they often begin rapidly and end quickly, which creates a desire for repeated dosing.
Methamphetamine stimulates dopaminergic (dopamine-releasing nerve fibers) and noradrenergic (norepinephrine-releasing nerve fibers) nerve endings, leading to the release of hormones known as dopamine (which is directly related to pleasure, motivation, satisfaction, and happiness) and norepinephrine (a hormone that affects happiness and brain and body functions). Molecules such as ephedrine or pseudoephedrine can be converted into methamphetamine through various chemical processes.
The bioavailability is approximately 70% when taken orally, while intravenous (IV) intake reaches up to 100%etabolized in the body via the hepatic pathway and excreted through the renal route. The half-life is approximately 8-10 hours .
Methacan be found in powder or pill form. Among users, it is also referred to by names such as meth, crystal, ice, crystal meth, crank, tina, ice cocaine, water blunts, and fire.
Exposure to methamphetamine causes cells to receive constant stimulation. The human body naturally reduces the number of receptors to which methamphetamine binds to regulate the number of stimuli. As a result of the decrease in the number of receptors that methamphetamine binds to, the individual cannot achieve the same effects from previous doses. To reach the pleasurable feeling experienced in earlier use, the person consumes higher doses of the substance. This situation is known as "tolerance development," leading the user to feel the need to use more of the substance each time, resulting in substance dependence with chronic use.
Methamphetamine stimulates dopaminergic and noradrenergic neurons located in the central nervous system. This stimulation causes the uncontrolled release of chemical substances known as dopamine and norepinephrine. Due to this uncontrolled release, these substances bind to various receptors, creating numerous stimuli. These stimuli can be observed in individuals as follows:
The symptoms of methamphetamine addiction can vary among users. However, the main symptoms and psychological effects can be listed as follows:
Young age, low education level, psychoactive substance use, adverse life conditions, unsuitable social environments, depression, anxiety disorders, various psychological disorders, traumatic losses, extreme weight loss desire, suicidal thoughts, curiosity, and many other factors can lead an individual to substance use and subsequently to addiction.
Many neurochemical events are under the control of the central nervous system. Since methamphetamine is a powerful central nervous system stimulant, it directly affects neurochemical events such as insomnia, appetite, heart rate, blood pressure, communication, attention, mood, and body temperature:
There is no approved medication for the treatment of methamphetamine addiction, but behavioral therapies combined with pharmacotherapy methods are applied as complementary treatments in the second phase of treatment.
Individuals using methamphetamine receive treatment under the supervision of counselors to maintain their motivation. During the therapy, small motivational rewards can serve as incentives to encourage progress.
Physical activities have a significant impact on individuals who have decided to quit methamphetamine use. Physical activities are crucial in reducing depression, anxiety disorders, and enhancing energy and the quality of social life.
Ceasing consumption, particularly avoiding intravenous use, steering clear of drug interactions that could cause serotonin syndrome, engaging in exercise, participating in social life, maintaining a balanced diet, and taking care of body and oral health can help individuals feel better psychologically and contribute to alleviating the challenging aspects of treatment.
The treatment of methamphetamine addiction is a very challenging process. Change is difficult and time-consuming. During this process, not only the patient but also their close family members have various responsibilities. The most important thing is to be patient and understanding throughout this process. Here are some things you can do for your loved one:
Last Updated Date: 10 August 2023
Publication Date: 10 August 2023
Psychiatry Department
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