Ataşehir
Nevrez Koylan
Prof.

Nevrez Koylan

He has been working as an internal medicine specialist and cardiologist at Anadolu Medical Center since 2011.

Speciality

  • Hypertension
  • Heart failure
  • Atherosclerosis
  • Coronary heart disease
  • Lipid disorders and chronic ischaemic heart disease

Education

  • University:
  • Istanbul University Istanbul Faculty of Medicine, Istanbul 1981
  • Residency Training:
  • Istanbul University Istanbul Faculty of Medicine, Department of Internal Medicine, Istanbul 1986

Institutions Worked At

Prof. Nevrez Koylan, graduated from Istanbul University, Istanbul Medical School. He completed his specialty education again at Istanbul University, Istanbul Medical School, Internal Medicine Department.  Prof. Koylan who is married and has a daughter, respectively, served as internal medicine specialist at Iğdır State Hospital, specialist research assistant at Istanbul University, Istanbul Medical School, Internal Medicine Department, and lecturer at Cardiology Department.   Prof. Koylan has been serving as an internal medicine specialist and cardiologist at Anadolu Medical Center since 2011.
  • American College of Cardiology (FACC)
  • European Society of Cardiology (FESC)
  • European Society of Hypertension 
  • International Atherosclerosis Society 
  • European Atherosclerosis Society 
  • European Association on Cardiovascular Prevention and Rehabilitation (EACPR) 
  • European Heart Failure Association 
  • Atherosclerosis Society (president and board member)
  • Society of Pharmacogenomics and Personalised Therapy (vice president)
  • New York Academy of Sciences (not active)
  • American Society of Hypertension (not active)
  • International College of Angiology (not active)
  • Turkish Society of Cardiology
  • Turkish Medical Association
  • Istanbul Medical Chamber

 Publications in foreign languages

Book

1. Büyüköztürk K, Koylan N, Meriç M, Korkut F, Özsaruhan Ö, Nişancı Y, Güven Ö, Deligönül U, Erzengin F, Özkan E: The effect of oral verapamil in the treatment of essential hypertension. In: "Hypertension- The next decade: Verapamil in Focus", Eds.: A. Fleckenstein and JH Laragh, Churchill- Livingstone, p: 199- 204, 1987.

2. Buğra Z, Meriç M, Koylan N, Adalet K, Nişancı Y, Büyüköztürk K, Ertem G: Long- term effects of coronary angioplasty on signal averaged electrocardiogram. In: “Volumetto Estratto da ICPEP 93”, Editor: A. Oto, Monduzzi Editore S.p.A, Bologna, Italy, p. 15- 18, 1993.

3. Meriç M, Koylan N, Büyüköztürk K: Balloon Mitral Valvuloplasty. In: “Textbook of Angiology”, Ed. Chang JB, Springer- Verlag, New York, Berlin, Heidelberg, 2000. pp: 370- 380.

4. Özben B, Bilge, AK, Koylan N: Cardiovascular aging and cardiovascular diseases in the elderly. In “Frontiers in Neurodegenerative Disorders and Aging: Fundamental aspects, Clinical Perspectives and New Insights”. Eds. T. Özben and M Chevion. IOS Press, 2004, pp: 128- 149.

Articles

1. Ekmekçi A, Güven Ö, Meriç M, Koylan N: The effect of aspirin on steady state serum digoxin concentrations in man (preliminary report). Turkish J. Res. Med. Sci., 1: 19- 20, 1983.

2. Meriç M, Koylan N, Adalet K, Şamilgil Meriç M, Ekmekçi A, Büyüköztürk K, Ertem G, Özcan R: The clinical use of prazosin in the treatment of congestive heart failure. Med. Bull. Istanbul, 19: 19- 28, 1986.

3. Meriç M, Nişancı Y, Adalet K, Koylan N, Korkut F, Yaşa M, Ertem G: The value of programmed electrical stimulation of the heart in the diagnosis of occult preexcitation syndrome. Med. Bull. Istanbul, 20: 17- 26, 1987.

4. Meriç M, Adalet K, Koylan N, Karabulut N, Arseven A, Ertem G: Treatment of essential hypertension. A comparative study of labetalol and propranolol. Clin. Trials J., 25: 181- 194, 1988.

This article cited in:

a) Anonymous: Bibliography Of The Current World Literature In Hypertension. J Hypertens 6 (9): H31-H34, 1988

5. Güven Ö, Koylan N, Öztürk N, Meriç M, Ekmekçi A, Güler K: The effect of aspirin on steady state serum digoxin concentrations and digoxin clearence in patients with congestive heart failure. Turk J Med Biol Res 2: 91- 96, 1991.

6. Seyithanoğlu BY, Atılgan D, Koylan N, Umman S, Meriç M, Ertem G: The importance of plasma fibrin destruction products within the first 24 hours of acute myocardial infarction. Med Bull Istanbul 24: 187- 196, 1991.

7. Meriç M, Gören T, Atılgan D, Eren N, Çubukçu A, Koylan N: Metabolic, hematological, and cardiac effects of long- term Isradipine treatment in mild- to- moderate essential hypertension. J Cardiovasc Pharmacol. 1992;19 Suppl 3:S58-60.

This article cited in:

a) Blecker D: Antihypertensive Therapy With Isradipine In Patients With Special Safety Concerns. Angiology 45 (12): 997-1008, 1994.

b) Marcus AO: Antihypertensive Therapy With The Calcium-Channel Blocker Isradipine - An Appropriate Choice For The Diabetic Patient With Hypertension - A Review Curr Ther Res Clin E 54 (6): 763-778 Dec 1993

8. Beşışık F, Koylan N, Umman S, Nişancı Y: Cardiac abnormalities and complications in a patient with Emery- Dreifuss muscular dystrophy. Med Bull Istanbul 26: 92- 98, 1993.

9. Yılmaz E, Adalet K, Yılmaz G, Badur S, Erzengin F, Koylan N, Özsaruhan Ö, Ertem G, Büyüköztürk K: Importance of serum anticardiolipin antibody levels in coronary heart disease. Clin Cardiol 17: 117- 121, 1994.

This article cited in:

a) Gurlek A, Ozdol C, Pamir G, et al. Association between anticardiolipin antibodies and recurrent cardiac events in patients with acute coronary syndrome. INTERNATIONAL HEART JOURNAL 46 (4): 631-638 JUL 2005

b) Brey RL, Chapman J, Levine SR, et al. Stroke and the antiphospholipid syndrome: consensus meeting Taormina 2002. LUPUS 12 (7): 508-513 2003

c) Berliner JI, Rybicki AC, Kaplan RC, et al. Elevated levels of Factor XI are associated with cardiovascular disease in women. THROMBOSIS RESEARCH 107 (1-2): 55-60 JUL 15 2002.

d) Reshetnyak TM, Kotelnikova GP, Fomitcheva OA, et al. Cardiological aspects of the antiphospholipid syndrome. Part I. Valvular lesions in the primary and secondary antiphospholipid syndrome and systemic lupus erythematosus. KARDIOLOGIYA 42 (8): 38-43 2002

e) Brey RL, Abbott RD, Curb JD, Et Al. Beta(2)-Glycoprotein 1-Dependent Anticardiolipin Antibodies And Risk Of Ischemic Stroke And Myocardial Infarction - The Honolulu Heart Program. Stroke 32 (8): 1701-1706, 2001.

f) Seijas M, Vazquez CM, Rivera A, Et Al. Prevalence Of Anti-Phospholipid Syndrome Among Patients Aged Less Than 65 Years With Acute Myocardial Infarction. Rev Clin Esp 201 (3): 118-121, 2001

g) Brighton TA, Chesterman CN: The Clinical Significance Of Antiphospholipid Antibodies In Patients Without Autoimmune Disease. Aust Nz J Med 30 (6): 693-703, 2000

h) Petri M. Epidemiology Of The Antiphospholipid Antibody Syndrome. J Autoimmun 15: (2) 145-151 Sep 2000

i) Guler N, Bilge M, Eryonucu B, et al. Relation between left ventricular and/or left atrial thrombus and anticardiolipin antibodies in patients with acute myocardial infarction. AMERICAN JOURNAL OF CARDIOLOGY 85 (11): 1391+ JUN 1 200

j) Limaye V, Beltrame J, Cook R, Et Al. Evaluation Of Antibodies To Beta 2-Glycoprotein 1 In The Causation Of Coronary Atherosclerosis As Part Of The Antiphospholipid Syndrome. Aust Nz J Med 29: (6) 789-793 Dec 1999

k) Zuckerman E, Toubi E, Shiran A, Et Al. Anticardiolipin Antibodies And Acute Myocardial Infarction In Non-Systemic Lupus Erythmatosus Patients: A Controlled Prospective Study. Am J Med 101: (4) 381-386 Oct 1996

l) Triplett Da. Protean Clinical Presentation Of Antiphospholipid-Protein Antibodies (Apa). Thromb Haemostasis 74: (1) 329-337 Jul 1995.

10. Koylan N, Öncül A, Mercanoğlu F, Orak E, Erzengin F, Büyüköztürk K: The acute effects of cilazapril on left ventricular diastolic functions. J Cardiovasc Pharmacol 24 (Suppl. 3): S42- S44, 1994. 

This article cited in:

a) Wachtell K, Bella JN, Rokkedal J, Et Al. Change In Diastolic Left Ventricular Filling After One Year Of Antihypertensive Treatment - The Losartan Intervention For Endpoint Reduction In Hypertension (LIFE) Study. Circulation 105 (9): 1071-1076,  2002.

11. Özsaruhan Ö, Öncül A, Nişancı Y, Umman S, Koylan N, Emel O, Büyüköztürk K, Ertem G: Influence of global system of mobile telephones on permanent pacemakers. Reblampa 8: 157- 158, 1995.

12. Adalet K, Nalbantgil İ, Kılıççıoğlu B, Koylan N, Buğra Z, Adalet I, Orak E, Umman F,Erzengin F, Büyüköztürk K: Multicenter double blind patient comparative trial with benazepril versus captopril in the treatment of mild to moderate hypertension. Med Bull Istanbul 28: 1- 9, 1995.

13. Umman B, Meriç M, Umman S, Koylan N, Adalet K, Nişancı Y, Ertem G: The effects of coronary angioplasty on the global and regional left ventricular function in patients with angina pectoris after anterior myocardial infarction. Int J Angiol 6:199-202, 1997.

14. Buğra Z, Koylan N, Vural A, Erzengin F, Umman B, Yilmaz E, Meriç M, Büyüköztürk  K. Left ventricular geometric patterns and QT dispersion in untreated essential hypertension. Am J Hypertens 11(10):1164-70, 1998. 

This article cited in:

a) Tuncer M, Güneş Y, Güntekin U, et al. Association of increased QTc dispersion and right ventricular hypertrophy. MEDICAL SCIENCE MONITOR 2008, 14(2): CR102-CR105.

b) Gür M, Yılmaz R, Demirbağ R, et al. Relationship between the elastic properties of aorta and QT dispersion in newly diagnosed arterial adult hypertensives. ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY 2007, 7(3): 275-280.

c) Girardot D, Jover B, Moles JP, et al. Chronic nitric oxide synthase inhibition prevents new coronary capillary generation. J Cardiovasc Pharmacol 44 (3): 322-328 SEP 2004

d) Balcı B, Yılmaz O, Yeşildağ O: The influence of ambulatory blood pressure profile on left ventricular geometry. Echocardiography-A Journal Of Cardiovascular Ultrasound And Allied Techniques 21 (1): 7-10 JAN 2004

e) Salles GF, Cardoso CRL, Deccache W: Multivariate associates of QT interval parameters in diabetic patients with arterial hypertension: importance of left ventricular mass and geometric patterns. Journal Of Human Hypertension 17 (8): 561-567 AUG 2003.

f) Seara FJG, Juanatey JRG, Sande JLM, et al. Long-term improvement of QT dispersion is unaffected by short-term changes in blood pressure during treatment of systemic hypertension with enalapril. Annals Of Noninvasive Electrocardiology 8 (1): 47-54 JAN 2003

g) Oikarinen L, Nieminen MS, Viitasalo M, et al. Relation of QT interval and QT dispersion to echocardiographic left ventricular hypertrophy and geometric pattern in hypertensive patients. The LIFE study. J Hypertens 19 (10): 1883-1891, 2001

h) Wolk R, Mazurek T, Lusawa T, et al. Left ventricular hypertrophy increases transepicardial dispersion of repolarisation in hypertensive patients: a differential effect on QTpeak and QTend dispersion. Eur J Clin Invest 31 (7): 563-569, 2001.

i) Kajander OA, Kupari M, Laippala P, et al. Coronary artery disease modifies left ventricular remodelling due to heavy alcohol consumption. Alcohol Clin Exp Res 25 (2): 246-252, 2001.

j) Hennersdorf MG, Strauer BE. Arterial hypertension and cardiac arrhythmias J Hypertens 19 (2): 167-177, 2001.

k) Malik M, Batchvarov VN. Measurement, interpretation and clinical potential of QT dispersion. J Am Coll Cardiol 36 (6): 1749-1766, 2000.

15. Onat A, Tokgözoğlu L, Soydan İ, Sansoy V, Koylan N, Mahley RW. Higher Efficacy of 10 mg/day of Simvastatin in Turkish Patients with Hyperlipidemia,  Türk Kardiyol Dern Arş 2000; 28:635-642

16. Onat A, Soydan I, Tokgözoğlu L, Sansoy V, Koylan N, Domaniç N, Ural D for the Riskburden Study Group: Guideline implementation in a multicenter study with an estimated 44% relative cardiovascular event risk reduction. CLINICAL CARDIOLOGY 26(5): 243- 249, 2003. 

This article cited in:

a) van Wyk JT, van Wijk MAM, Sturkenboom MCJM, et al. Identification of the four conventional cardiovascular disease risk factors by Dutch general practitioners. CHEST 128 (4): 2521-2527, 2005.

b) Skrtic S, Niklason A, Leoo T, et al. Risk factor identification and assessment in hypertension and diabetes (RIAHD) study. BLOOD PRESSURE 2006, 15(6): 367-374.

17. Oflaz H, Türkmen A, Kocaman O, Erdoğan D, Meriç M, Öncül A, Koylan N, Yılmaz E, Yılmaz C, Selçukbiricik F, Kaşıkcıoğlu E, Sever MS: Is there a relation between duration of cyclosporine usage and right and left ventricular function in renal transplant patients?: Tissue Doppler echocardiography study. Transplantation Proceedings 36 (5): 1380- 1384, 2004.

This article cited in:

a) Balal M, Koç M, Paydaş S, et al. Daily blood pressure control is not sufficient to regress cardiac hypertrophy and dysfunction: A bi-ventricular tissue Doppler echocardiographic study. NEPHROLOGY 2007, 12(2):140-146.

18. Julius S, Kjeldsen SE, Weber M, Brunner HR, Ekman S, Hansson L, Hua T, Laragh J, MacInness GT, Michell L, Plat F, Schork A, Smith B, Zanchetti A for the Value Trial Group (Koylan N in Steering Committee list and Investigator list): Outcomes in hypertensive patients at high cardiovascular risk treated with regimes based on valsartan or amlodipine: The Value Randomized Trial. Lancet 363(9426): 2022-2031 2004. 

This article cited in (total 596):

19. Koylan N, Bilge, AK, Adalet K, Mercanoğlu F, Büyüköztürk K: Comparison of the effects of trimetazidine and diltiazem on exercise performance in patients with coronary heart disease. The Turkish Trimetazidine Study (TTS). Acta Cardiologica 59(6):644- 650, 2004.

This article cited in:

a) McCullough PA. Ranolazine: Focusing on angina pectoris. DRUGS OF TODAY 42 (3): 177-183 MAR 2006.

b) Marzilli M, Affinito S. Meeting the challenge of chronic ischaemic heart disease with trimetazidine. CORONARY ARTERY DISEASE 16: S23-S27 Suppl. 1 NOV 2005.

20. Bilge AK, Atılgan D, Tükek T, Özcan M, Özben B, Koylan N, Meriç M. Effects of amlodipine and fosinopril on heart rate variability and left ventricular mass in mild-to-moderate essential hypertension. Int J Clin Pract, March 2005, 59, 3, 306–310

a) Miziara AN, Molina RJ, Ferreira BDC, et al. Cardiac autonomic modulation in hypertensive patients with Chagas' disease. ACTA TROPICA 2006, 97(2): 188-195.

b) Frishman WH. Calcium channel blockers: Differences between subclasses. AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS 2007, 7(Suppl.1): 17-23.

c) Weir MR. Calcium channel blockers: Their pharmacologic and therapeutic role in hypertension. AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS 2007, 7(Suppl.1): 5- 15.

d) Michaels AD, Bart BA, Pinto T, et al. The effects of enhanced external counterpulsation on time- and frequency-domain measures of heart rate variability. JOURNAL OF ELECTROCARDIOLOGY 2007, 40(6): 515-521. 

 

21. Pamukçu B, Oflaz H, Acar RD, Umman S, Koylan N, Umman B, Nişancı Y. The role of exercise on platelet aggregation in patients with stable coronary artery disease: exercise induces aspirin resistant platelet activation. J Thromb Thrombolysis. 2005 Aug;20(1):17-22. 

This article cited in:

a) Pamukçu B, Oflaz H, Öncüll A, et al. The role of aspirin resistance on outcome in patients with acute coronary syndrome and the effect of clopidogrel therapy in the prevention of major cardiovascular events. JOURNAL OF THROMBOSIS AND THROMBOLYSIS 2006, 22(2): 103-110.

b) Lordkipanidze M, Pharand C, Palisaitis DA, et al. Aspirin resistance: Truth or dare. PHARMACOLOGY & THERAPEUTICS 2006, 112(3): 733-743.

c) Falluji N, Steinhubl SR. Variable response to antiplatelet therapy: What does it mean to clinicians? Source: CLEVELAND CLINIC JOURNAL OF MEDICINE 2007, 74(1): 49-55.

d) Hovens MMC, Snoep JD, Eikenboom JCJ, et al. Prevalence of persistent platelet reactivity despite use of aspirin: A systematic review. AMERICAN HEART JOURNAL 2007, 153(2): 175-181.

e) Kahraman G, Şahin T, Kılıç T, et al. The frequency of aspirin resistance and its risk factors in patients with metabolic syndrome. INTERNATIONAL JOURNAL OF CARDIOLOGY 2007, 115(3): 391-396.

f) Pamukçu B, Oflaz H, Onur I, et al. Clinical relevance of aspirin resistance in patients with stable coronary artery disease: a prospective follow-up study (PROSPECTAR). BLOOD COAGULATION & FIBRINOLYSIS 2007, 18(2): 187-192.

g) Pamukçu B. A review of aspirin resistance; definition, possible mechanisms, detection with platelet function tests, and its clinical outcomes. JOURNAL OF THROMBOSIS AND THROMBOLYSIS 2007, 23(3): 213-222.

h) Poulsen TS, Jorgensen B, Korsholm L, et al. Prevalence of aspirin resistance in patients with an evolving acute myocardial infarction. THROMBOSIS RESEARCH 2007, 119(5): 555-562.

i) Pamukçu B, Oflaz H, Onur M, et al. Aspirin-resistant platelet aggregation in a cohort of patients with coronary heart disease. BLOOD COAGULATION & FIBRINOLYSIS 2007, 18(5): 461-465.

j) Pamukçu B, Oflaz H, Onur L, et al. Relationship between the serum sCD40L level and aspirin-resistant platelet aggregation in patients with stable coronary artery disease 

CIRCULATION 2008, 72(1): 61-66. 

k) Crescente M, Di Castelnuovo A, Lacoviello L, et al. Response variability to aspirin as assessed by the platelet function analyzer (PFA)-100 - A systematic review. THROMBOSIS AND HAEMOSTASIS 2008, 99(1): 14-26. 

l) Tseeng S, Arora R. Aspirin resistance: Biological and clinical implications 

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS 2008, 13(1): 5-12.

m) Pamukçu B, Oflaz H, Nişancı Y. A current problem in atherothrombotic diseases aspirin resistance: Definition, mechanisms, determination with laboratory tests and clinical implications. ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY 2007, 7(suppl.2): 20-26. 

22. Koylan N, Acartürk E, Canberk A, Çağlar N, Çağlar S, Erdine S, Güneri S, İlerigelen B, Kabakçı G, Önder R, Sağkan O, Büyüköztürk K. Effect of irbesartan monotherapy compared with ACE inhibitors and calcium-channel blockers on patient compliance in essential hypertension patients: A multicenter, open-labeled, three-armed study. Blood Press. 2005 Jul 1;14 Suppl 1:23-31.

This article cited in:

a) Hedner T, Narkiewicz K, Kjeldsen SE. Hypertension control - A global challenge. Source: BLOOD PRESSURE 2005, 14(Suppl.1): 4-5.

23. Oflaz H, Cuhadaroğlu C, Pamukçu B, Meriç M, Ece T, Kaşıkçıoğlu E, Koylan N. Endothelial Function in Patients with Obstructive Sleep Apnea Syndrome but without Hypertension. Respiration 2006, 73(6): 751- 756.

This article cited in:

a) Aittokallio J, Polo O, Hiissa J, et al. Overnight variability in transcutaneous carbon dioxide predicts vascular impairment in women. EXPERIMENTAL PHYSIOLOGY 2008, 93(7): 880- 891.

b) Cherniack NS. N-terminal pro-B-type naturetic peptide (NTBNP): so much promise and such a disappointment. SLEEP AND BREATHING 2008, 12(1): 3-5.

c) Fritscher LG, Canani S, Mottin CC, et al. Bariatric surgery in the treatment of obstructive sleep apnea in morbidly obese patients. RESPIRATION  2007, 74(6): 647- 652.

d) Ursavas A, Karadag M, Rodoplu E, et al. Circulating ICAM-1 and VCAM-1 levels in patients with obstructive sleep apnea syndrome. RESPIRATION 2007, 74(5): 525- 532.

e) Ainslie PN, Barach A, Cummings KJ, et al. Cardiorespiratory and cerebrovascular responses to acute poikilocapnic hypoxia following intermittent and continuous exposure to hypoxia in humans. JOURNAL OF APPLIED PHYSIOLOGY 2007, 102)5): 1953- 1961.

f) Cherniack NS. What's a good night's sleep worth? RESPIRATION 73(6): 735-736.

24. Julius S, Weber MA, Kjeldsen SE, McInnes GT, Zanchetti A, Brunner HR, Laragh J, Schork MA, Hua TA, Amerena J, Balazovjech I, Cassel G, Herczeg B, Koylan N, Magometschnigg D, Majahalme S, Martinez F, Oigman W, Seabra Gomes R, Zhu JR.  The Valsartan Antihypertensive Long-Term Use Evaluation (VALUE) trial: outcomes in patients receiving monotherapy. Hypertension. 2006 48(3):385-91.

This article cited in:

a) Anonymous. Valsartan appears more effective than amlodipine in prevent HF, diabetes in patients with hypertension. Formulary 2006, 41(10): 527.

b) Sica DA. The valsartan antihypertensive long-term use evaluation trial - A study in contrasts. HYPERTENSION 2006, 48(3): 362-363.

c) Kaplan NM. Clinical trials for hypertension - Expectations fulfilled and unfulfilled. HYPERTENSION 2007, 49(2): 257-259.

d) Sigurdsson ST, Strandgaard S: Blood pressure lowering in acute ischaemic stroke: an update on the role of angiotensin receptor blockers. JOURNAL OF HYPERTENSION 2007, 25(4): 743-745.

e) Dusing R: New-onset diabetes mellitus during antihypertensive treatment. DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT 2007, 132(13): 689-695.

f) Chrysant SG, Sugimoto DH, Lefkowitz M, et al.: The effects of high-dose amlodipine/benazepril combination therapies on blood pressure reduction in patients not adequately controlled with amlodipine monotherapy. BLOOD PRESSURE 2007, 16 (Suppl.1): 10-17. 

g) Oparil S, Yarows SA, Patel S, et al. Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomised, double-blind trial. LANCET 2007, 370(9583): 221-229.

h) Epstein BJ, Vogelz K, Palmer BF. Dihydropyridine calcium channel antagonists in the management of hypertension. DRUGS 2007, 67(9): 1309-1327.

i) Wang JG, Li Y. Response to can large-scale trials or meta-analyses demonstrate blood pressure-independent effect of angiotensin receptor blockers? HYPERTENSION 2007, 50(4): E74-E74.

j) Aulakh GK, Sodhi RK, Singh M. An update on non-peptide angiotensin receptor antagonists and related RAAS modulators. LIFE SCIENCES 2007, 81(8): 615-639.

k) Yamamoto E, Kataoka K, Shintaku H, et al. Novel mechanism and role of angiotensin II-Induced vascular endothelial injury in hypertensive diastolic heart failure. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2007, 27(12): 2569-2575. 

l) Kjeldsen SE, Oparil S, Narkiewicz K, et al. Ambulatory blood pressure adds to explaining benefits of AT-1 receptor blockade in the treatment of left ventricular hypertrophy. BLOOD PRESSURE 2007, 16(6): 344-346. 

m) Weber MA. Secondary analysis of the VALUE trial: Intriguing new questions. CURRENT HYPERTENSION REPORTS 2007, 9(4): 261-263. 

n) Choy CK, Rodgers JE, Nappi JM, et al. Type 2 diabetes mellitus and heart failure. PHARMACOTHERAPY 2008, 28(2): 170-192.

o) Shafiq MM, Menon DV, Victor RG. Oral direct renin inhibition: Premise, promise, and potential limitations of a new antihypertensive drug. AMERICAN JOURNAL OF MEDICINE 2008, 121(4): 265-271. 

p) Papadopoulosa DP, Papademetriou V. Aggressive blood pressure control and stroke prevention: role of calcium channel blockers. JOURNAL OF HYPERTENSION 2008, 26(5): 844-852. 

q) Williams B. The year in hypertension. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2008, 51(18): 1803-1817. 

25. Büyüköztürk  K, İlerigelen B, Kabakçı G, Koylan N, Kozan O. Intensive Cardiovascular Examination regarding Blood pressure levels: Evaluation of Risk Groups. ICEBERG study. BLOOD PRESSURE 2006, 15(5): 291-301.  

26. Pamukçu B, Oflaz H, Onur M, Öncül A, Umman B, Koylan N, Buğra Z, Meriç M, Nişancı Y. Aspirin-resistant platelet aggregation in a cohort of patients with coronary heart disease. BLOOD COAGULATION & FIBRINOLYSIS 2007, 18(5): 461-465. 

This article cited in:

a) Ghosh K, Shetty S, Mota L. Aspirin resistance in patients with coronary artery disease - which test to use in routine management? BLOOD COAGULATION & FIBRINOLYSIS 2008, 19(4): 324-326.

b) Crescente M, Di Castelnuovo A, Lacoviello L, et al. Response variability to aspirin as assessed by the platelet function analyzer (PFA)-100 - A systematic review. THROMBOSIS AND HAEMOSTASIS 2008, 99(1): 14- 26.

27. Deedwania P, Stone PH, Merz CNB, Cosin-Aguilar J, Koylan N, Luo D, Ouyang P, Piotrowicz R, Schenck-Gustafsson K, Sellier P, Stein JH, Thompson PL, Tzivoni D. Effects of intensive versus moderate lipid-lowering therapy on myocardial ischemia in older patients with coronary heart disease - Results of the Study Assessing Goals in the Elderly (SAGE). CIRCULATION 2007, 115(6):700-707.

This article cited in:

a) Gotto AM:  Statin therapy and the elderly SAGE advice?  CIRCULATION  2007, 115(6): 681-683.

b) Wenger NK, Lewis SJ, Herrington DM, et al. Outcomes of using high- or low-dose atorvastatin in patients 65 years of age or older with stable coronary heart disease. ANNALS OF INTERNAL MEDICINE  2007, 147(1): 1-9.

c) Davidson MH: Rosuvastatin in elderly patients. DRUGS & AGING 2007, 24(11):933-944.

d) Arca M. Atorvastatin - A safety and tolerability profile. DRUGS 2007, 67(Suppl.1): 63-69.

e) Duivenvoorden R, Nederveen AJ, De Groot E, et al. Atherosclerosis imaging as a benchmark in the development of novel cardiovasular drugs. CURRENT OPINION IN LIPIDOLOGY 2007, 18(6):613-621.

f) Josan K, Majumdar SR, McAlister FA. The efficacy and safety of intensive statin therapy: a meta-analysis of randomized trials. CANADIAN MEDICAL ASSOCIATION JOURNAL 2008, 178(5): 576-584

g) Jolicoeur EM, Granger CB, Henry TD, et al. Clinical and research issues regarding chronic advanced coronary artery disease: Part I: Contemporary and emerging therapies. AMERICAN HEART JOURNAL 2008, 155(3): 418-434.

h) Shepherd J. Monotherapy vs combination therapy for dyslipidemia in the elderly. AMERICAN JOURNAL OF GERIATRIC CARDIOLOGY 2008, 17(2):108-113.

i) Maroo BP, Lavie CJ, Milani RV. Efficacy and Safety of intensive statin therapy in the elderly. AMERICAN JOURNAL OF GERIATRIC CARDIOLOGY 2008, 17(2):92-100.

j) Robinson JG. Models for describing relations among the various statin drugs, low-density lipoprotein cholesterol lowering, pleiotropic effects, and cardiovascular risk. AMERICAN JOURNAL OF CARDIOLOGY 2008, 101(7): 1009-1015.

k) Bybee KA, Lee JH, O'Keefe JH: Cumulative clinical trial data on atorvastatin for reducing cardiovascular events: the clinical impact of atorvastatin. CURRENT MEDICAL RESEARCH AND OPINION 2008, 24(4): 1217-1229.

28. Kabakçı G, Koylan N, İlerigelen B, Kozan Ö, Büyüköztürk K. The impact of dyslipidemia on cardiovascular risk stratification of hypertensive patients and association of lipid profile with other cardiovascular risk factors: Results from the ICEBERG study. Türk Kardiyol Dern Arş. (Arch Turk Soc Cardiol) 2007;35(8):458-466

29. Kabakçı G, Koylan N, Kozan O, Büyüköztürk  K, İlerigelen B; ICEBERG Investigators. Evaluation of the metabolic syndrome in hypertensive patients: results from the ICEBERG Study. J Cardiometab Syndr. 2007 Summer;2(3):168-73.

30. Kozan O, Büyüköztürk  K, İlerigelen B, Kabakçı G, Koylan N; ICEBERG Investigators. The impact of plasma high-sensitivity C-reactive protein levels on cardiovascular risk stratification of hypertensive patients: results of the ICEBERG study. J Clin Hypertens (Greenwich). 2007 Jul;9(7):500-5.

31. Julius S, Palatini P, Kjeldsen SE, Zanchetti A, Weber MA, McInnes GT, Brunner HR, Mancia G, Schork MA, Hua TA, Holzhauer B, Zappe D, Majahalme S, Jamerson K, and Koylan N. Usefulness of Heart Rate to Predict Cardiac Events in Treated Patients with High Risk Systemic Hypertension. Amer J Cardiol (accepted and scheduled for publication in March 2012).

Academic Papers

1. Ekmekçi A, Güven Ö, Meriç M, Sandalcı Ö, Koylan N, Özcan R, Deligönül U, Büyüköztürk K, Işık K, Berkmen R, Ertem G: The effect of aspirin on steady state serum digoxin levels in cardiac patients. Third Joint Meeting of the Working Groups of European Society of Cardiology, 5- 7 September 1983, SPA, Belgium. European Heart J, 4 (Suppl. E): 42, 1983.

THIS PAPER IS INDEXED IN SCI.

2. Koylan N, Ekmekçi A, Erdemgüler T, Çalangu S, Oral T, Meriç M, Canberk A: The acute antihypertensive effectiveness of sublingual nifedipine compared with intravenous furosemide in hypertensive emergencies. Cardiovascular Pharmacotherapy International Symposium, 22- 25 April 1985, Geneva, Switzerland. Abst. Book No: 14.

3. Büyüköztürk K, Koylan N, Meriç M, Korkut F, Özsaruhan Ö, Nişancı Y, Güven Ö, Deligönül U, Erzengin F, Özkan E: The effect of oral verapamil in the treatment of essential hypertension. 

a) Second European Meeting on Hypertension, 9- 12 June 1985, Milan, Italy. Abst. Book (Ricerca Scientifica ed Educazione Permanente); suppl. no: 49, Abst. no: 68, 1985. 

b) International Symposium on Calcium and Calcium Antagonists in Hypertension - Satellite Symposium to the Second European Meeting on Hypertension, 9 June 1985, Milan, Italy. 

c) Hypertension- The next decade: Verapamil in focus. 10- 11 October, 1986, Berlin ICC, West Germany.

4. Büyüköztürk K, Levi S, Meriç M, Koylan N, Erzengin F, Özsaruhan Ö, Özkan E, Özcan R: The effects of intravenous verapamil in essential hypertension. Xth World Congress of Cardiology, 14- 19 September 1986, Washington DC, USA. Abst. Book, No: 1112.

5. Ekmekçi A, Boztaş G, Meriç M, Koylan N, Adalet K, Canberk A, Ertem G, Özcan R: Investigation of the erythrocyte fluid volume in normotensive children of patients with essential hypertension. Xth World Congress of Cardiology, 14- 19 September 1986, Washington DC, USA. Abst. Book, No: 2081.

6. Ekmekçi A, Seyithanoğlu Y, Meriç M, Koylan N, Adalet K, Ertem G, Özcan R: The importance of serum F/FDP level in determination of short term prognosis after myocardial infarction. Xth World Congress of Cardiology, 14- 19 September 1986, Washington DC, USA. Abst. Book, No: 2082.

7. Ekmekçi A, Kazancıoğlu R, Meriç M, Adalet K, Koylan N, Ertem G, Özcan R: The effects of beta- blocker agents with or without intrinsic sympathomimetic activity on plasma lipid fractions. The Mediteranean Meeting on Cardiology, 7- 9 October 1986, Nice, France.

8. Meriç M, Gören T, Atılgan D, Eren N, Çubukçu A, Koylan N: The metabolic, hematologic and cardiologic effects of the long term isradipine treatment patients with mild and moderate in hypertension. Fifth European Meeting on Hypertension, 7- 10 June 1991, Milan, Italy. Ricerca Scientifica ed Educazione Permanente, Supplemento n. 90- 1991, Abst. no: 454.

9. Yılmaz E, Adalet K, Yılmaz G, Badur S, Erzengin F, Koylan N, Özsaruhan Ö, Çetin ET, Büyüköztürk K: Importance of serum anticardiolipin antibody levels in coronary heart disease (a preliminary study). XIIIth Congress of the European Society of Cardiology, 18- 22 August 1991, Amsterdam, The Netherlands. Eur Heart J 12: Abstract Supplement, August 1991, Abst no: P1082.

10. Nalbantgil İ, Adalet K, Orak E, Buğra Z, Umman B, Adalet I, Koylan N, Erzengin F, Büyüköztürk K: Multicenter, double- blind between patient comparative trial with benazepril and captopril in the treatment of mild to moderate hypertension. 5th International Symposium on Cardiovascular Pharmacotherapy, 10- 12 July 1993, Minneapolis, Minnesota, USA. Cardiovasc Drugs Ther 7 (Suppl 2): 419, 1993, Abst.no:119.

11. Buğra Z, Meriç M, Koylan N, Adalet K, Nişancı Y, Büyüköztürk K, Ertem G: Long- term effects of coronary angioplasty on signal averaged electrocardiogram. 4th International Congress on Cardiac Pacing and Electrophysiology, 3- 6 October 1993, Antalya, Turkey. Eur J Cardiac Pacing Electrophysiol 3 (Number 3)(Suppl.2A): A30, 1993, Abst.no: 87.

12. Umman B, Meriç M, Umman S, Koylan N, Adalet K, Nişancı Y, Ertem G: The effects of coronary angioplasty on the global and regional left ventricular function after anterior myocardial infarction in patients with angina pectoris. XVth Congress of the European Society of Cardiology, 29 August- 2 September 1993, Nice, France. Eur Heart J 14 (Abstract Supplement): 471, 1993. Abstract no: P2601.

13. Koylan N, Öncül A, Mercanoğlu F, Orak E, Erzengin F, Büyüköztürk K: The acute effects of cilazapril on left ventricular diastolic functions. A vascular protective concept in hypertension and heart failure- 4th International Symposium on Cilazapril, 26 November 1993, Istanbul, Turkey. Abstracts Book, p.25.

14. Koylan N, Altuğ T, Güzel Ö, Mercanoğlu F, Öncül A, Gündoğdu R: Lipoprotein(a) levels and its relation with other lipids in documented coronary artery disease patients and in healthy subjects. 4th Turkish- Polish Cardiology Days, 6- 7 June 1994, Istanbul, Turkey.Türk Kardiyol Dern Arş 22: 213, 1994.

15. Öncül A, Özsaruhan Ö, Umman S, Nişancı Y, Erzengin F, Koylan N, Meriç M, Büyüköztürk K, Ertem G: Comparison of 'Sensor blended and cross checked' rate of double sensored, doube chamber pacemakers with normals. Cardiostim 94- 9th International Congress, 12- 14 June 1994, Nice, France. Eur J Cardiac Pacing Electrophysiol 4(Suppl.4): 54, 1994. Abstract no: 227.

16. Koylan N, Altuğ T, Güzel Ö, Öncül A, Mercanoğlu F, Gündoğdu R, Ertem G: Interaction of lipid fractions and lipoprotein(a) in coronary heart disease. 36th Annual World Congress of International College of Angiology, 2- 9 July, 1994, New York City, New York, USA. Abstracts Book, p.72- 73.

17. Canberk A, Koylan N, Gülbaba G, Mercanoğlu F: The effect of nitrendipine on plasma endothelin-I levels. 36th Annual World Congress of International College of Angiology, 2- 9 July, 1994, New York City, New York, USA. Abstracts Book, p.73- 74.

18. Çefle K, Koylan N, Okur Ö, Adalet K, Orak E, Helvacı A, Mercanoğlu F, Meriç M, Ertem G, Büyüköztürk K: The effect of propafenone on signal averaged electrocardiogram. 36th Annual World Congress of International College of Angiology, 2- 9 July, 1994, New York City, New York, USA. Abstracts Book, p.76- 77.

19. Koylan N, Atılgan D, Canberk A, Buğra Z, Büyüköztürk K: Signal averaged electrocardiographic findings in mild to moderate essential hypertension. Joint XIIth World Congress of Cardiology and XVIth Congress of European Society of Cardiology, September 10- 14, 1994, Berlin, Germany. Eur Heart J 15: (Abstract Supplement, August 1994. Abstract no: P1557.

20. Öncül A, Özsaruhan Ö, Nişancı Y, Umman S, Buğra Z, Adalet K, Koylan N, Büyüköztürk K, Ertem G: Incidence of chronic atrial fibrillation in single or double chamber permanent pacing with or without rate response. Europace 95- 7th European Symposium on Cardiac Pacing, June 4- 7, 1995, Istanbul, Turkey. Pacing and Clinical Electrophysiology, 18(5): 1210, abst.no: 426.

21. Koylan N, Buğra Z, Vural A, Sezer A, Büyüköztürk K: The acute effects of nisoldipine on left ventricular diastolic function and QT dispersion in patients with mild to moderate essential hypertension. 2nd European Meeting on Calcium Antagonists, Amsterdam, The Netherlands, October 25- 27, 1995. Abstract Book, p.36.

22. Koylan N, Adalet K, Erzengin F, Büyüköztürk K, Cordan J, Oram E, Özbay G, Sağkan O, Timuralp B: The effects of slow release verapamil on exercise performance in patients with coronary heart disease. 2nd European Meeting on Calcium Antagonists, Amsterdam, The Netherlands, October 25- 27, 1995. Abstract Book, p.47.

23. Koylan N: New perspectives in the control of renin- angiotensin system: Angiotensin II antagonism and the expectations. Turkish German Joint Meeting on Hypertension and Atherosclerosis, 21- 25 April 1996, Marmaris, Turkey. Abstract Book p.49.

24. Canberk A, Delier H, Batum B, Üresin Y, Koylan N, Öncül A: Evaluation of glucose tolerance and insulin resistance syndrome in patients with mild to moderate essential hypertension. Turkish German Joint Meeting on Hypertension and Atherosclerosis, 21- 25 April 1996, Marmaris, Turkey. Abstract Book p.83.

25. Koylan N, Umman B, Azarbaz M, Erzengin F, Büyüköztürk K: The effects of various calcium antagonists on the late potentials and QT dispersion. Turkish German Joint Meeting on Hypertension and Atherosclerosis, 21- 25 April 1996, Marmaris, Turkey. Abstract Book p.95.

26. Buğra Z, Koylan N, Vural A, Umman B, Mercanoğlu F, Sağbaş A, Erzengin F, Meriç M, Büyüköztürk K: Left ventricular hypertrophy patterns and ventricular remodeling in patients with essential hypertension. Turkish German Joint Meeting on Hypertension and Atherosclerosis, 21- 25 April 1996, Marmaris, Turkey. Abstract Book p.130.

27. Buğra Z, Koylan N, Vural A, Erzengin F, Umman B, Yılmaz E, Meriç M, Büyüköztürk K: Left ventricular hypertrophy patterns, ventricular remodeling and QT dispersion in untreated essential hypertension. A) The American Society of Hypertension 20th. Scientific Meeting, San Francisco, USA, May 27- 30, 1997. Amer J Hypertens Abstract Issue10 (4): 53A, 1997. B) XIXth Congress of the European Society of Cardiology, Stockholm, Sweden, 24- 28 August 1997, Eur Heart J 18:116 (741), 1997.

28. Buğra Z, Mercanoğlu F, Vural A, Koylan N, Erzengin F, Büyüköztürk K: Short- term effects of the long- acting angiotensin converting enzyme inhibitor trandolapril on left ventricular diastolic filling indexes in hypertensive patients. The American Society of Hypertension 20th. Scientific Meeting, San Francisco, USA, May 27- 30, 1997. Amer J Hypertens Abstract Issue10 (4): D111, 1997.

29. Atılgan D, Koylan N, Akkaya V, Meriç M, Büyüköztürk K. Does mitral stenosis without atrial fibrillation have detrimental effects on left atrial appendage functions? A transesophageal echocardiographic study. XIIIth World Congress of Cardiology, April26- 30, 1998, Rio de Janeiro, Brazil. J Amer Coll Cardiol 31:188C, 1998.

30. Koylan N, Taşköprü İ, Karşıdağ K, Oflaz H, Büyüköztürk K: The use of heart rate variability in the diagnosis of diabetic autonomic neuropathy in patients with non insulin dependent diabetes mellitus. XIIIth World Congress of Cardiology, April26- 30, 1998, Rio de Janeiro, Brazil. J Amer Coll Cardiol 31:188C, 1998.

31. Koylan N, Taşköprü İ, Karşıdağ K, Oflaz H, Büyüköztürk K: QT dispersion as a new method for the diagnosis of diabetic autonomic neuropathy in patients with non insulin dependent diabetes mellitus. XIIIth World Congress of Cardiology, April26- 30, 1998, Rio de Janeiro, Brazil. J Amer Coll Cardiol 31:189C, 1998.

32. Koylan N, Pakhoo M, İspir T, Atılgan D, Meriç M, Büyüköztürk K: The comparison of the effects of perindopril and losartan on red cell membrane ATPase levels in patients with mild to moderate essential hypertension. . XIIIth World Congress of Cardiology, April26- 30, 1998, Rio de Janeiro, Brazil. J Amer Coll Cardiol 31:189C, 1998.

33. Koylan N, Pakhoo M, İspir T, Atılgan D, Meriç M, Büyüköztürk K: The comparison of the effects of perindopril and losartan on plasma malondialdehyde levels in patients with mild to moderate essential hypertension. . XIIIth World Congress of Cardiology, April26- 30, 1998, Rio de Janeiro, Brazil. J Amer Coll Cardiol 31:189C, 1998.

34. Küçükbasmacı Ö, Anğ Ö, Bozkaya E, Küçükbasmacı F, Koylan N: Association of helicobacter pylori infection with coronary heart disease and cardiovascular risk factors. 8th. International Congress of Infectious Diseases, Boston, MA, USA, May 15- 18, 1998.

35. Koylan N, Topbaş A, Erzengin F: The effects of losartan on prolactin, TSH and cortisol plasma levels. 46th World Annual Assembly of the American College of Angiology,Kamuela, Hawaii, USA, October 3- 8 1999.

36. Tokgözoğlu L, Koylan N, Soydan I, Domaniç N, Enar R, Atalar E, Kayıkçıoğlu M. Effects of low dose pravastatin theraphy on endothelium generated mediators and thrombotic tendency in patients with hypercholesterolaemia. XXIIth Congress of the European Society of Cardiology, Eur Heart J 21: P974 Suppl. S, 2000.

This paper cited in:

a) Bang LM, Goa KL. Pravastatin - A review of its use in elderly patients. DRUGS & AGING 20 (14): 1061-1082 2003

b) Stenestrand U, Wallentin L. Early statin treatment following acute myocardial infarction and 1-year survival. JAMA-J Am Med Assoc 285 (4): 430-436, 2001

37. Koylan N, Sever MŞ, İlerigelen B, Önder R, Çağlar Ş: The gap between the clinical measurements and ambulatory blood pressure means in the Treatment and Ambulatory Blood Pressures (TRAP) study. 4th International Symposium on Angiotensin II Antagonism, 3- 5 April 2001, London, UK. Abstract Book PC 46.

38. Koylan N, Sever MŞ, İlerigelen B, Önder R, Çağlar Ş: The frequency and duration of white coat effect and the reliability of 27- hour ambulatory blood pressure monitoring in the Treatment and Ambulatory Blood Pressures (TRAP) study. 4th International Symposium on Angiotensin II Antagonism, 3- 5 April 2001, London, UK. Abstract Book PC 47.

39. Koylan N, Sever MŞ, İlerigelen B, Önder R, Çağlar Ş: Morning surge of blood pressure in the elderly is more prominent than younger patients in the Treatment and Ambulatory Blood Pressures (TRAP) study. 4th International Symposium on Angiotensin II Antagonism, 3- 5 April 2001, London, UK. Abstract Book PC 54.

40. Koylan N, Sever MŞ, İlerigelen B, Önder R, Çağlar Ş: The gap between the clinical measurements and ambulatory blood pressure means in the Treatment and Ambulatory Blood Pressures (TRAP) study. American Society of Hypertension 16th Annual Scientific Meeting and Exposition, 15- 19 May, 2001, San Francisco, CA, USA. American Journal of Hypertension 14(4): 52A, 2001 

41. Koylan N, Sever MŞ, İlerigelen B, Önder R, Çağlar Ş: The frequency and duration of white coat effect and the reliability of 27- hour ambulatory blood pressure monitoring in the Treatment and Ambulatory Blood Pressures (TRAP) study. American Society of Hypertension 16th Annual Scientific Meeting and Exposition, 15- 19 May, 2001, San Francisco, CA, USA. American Journal of Hypertension 14(4): 52A, 2001.

42. Koylan N, Sever MŞ, İlerigelen B, Önder R, Çağlar Ş: Morning surge of blood pressure in the elderly is more prominent than younger patients in the Treatment and Ambulatory Blood Pressures (TRAP) study. American Society of Hypertension 16th Annual Scientific Meeting and Exposition, 15- 19 May, 2001, San Francisco, CA, USA. American Journal of Hypertension 14(4): 52A, 2001.

43. Atılgan D, Koylan N, Tükek T, Bilge AK, Özcan M, Korkut F, Meriç M: Effects of amlodipine and fosinopril on heart rate variability and left ventricular mass in essential hypertension. American Society of Hypertension 17th Annual Scientific Meeting, 14- 18 May, 2002, New York Marriott Marquis, New York, NY, USA. American Journal of Hypertension 15(4):  35A, 2002.

44. Tokgözoğlu L, Salomon H, Bernard M- D, Koylan N, Görpe U, Akgün G, Akalın S, Yüksel H, Domaniç N, Arslan M, Satman İ, Erdoğan G: An open- label clinical trial evaluating the efficacy and safety of co- micronized fenofibrate (200 mg capsules) once a day in Turkish dyslipidemic patients over 12 weeks of treatment. 6th International Symposium on Global Risk on Coronary Heart Disease and Stroke: Assassment, Prevention and treatment. Florence, Italy, June 12- 15, 2002.

45. Koylan N, Acartürk E, Çağlar N, Çağlar S, Erdine S, Güneri S, İlerigelen B, Kabakçı G, Önder R, Sağkan O: Effect of irbesartan monotherapy compared with ACE inhibitors and calcium channel blockers on patient compliance in patients with essential hypertension: A multicenter, randomized, open- cohort study. Thirteenth European Meeting Of Hypertension, June 13- 17, 2003, Milan, Italy,. J Hypertens 21(Suppl.4) : S73, P1.191, 2003. 

THIS PAPER IS INDEXED IN SCI.

46. Oflaz H, Çuhadaroğlu Ç, Pamukçu B, Bilge AK, Ece T, Koylan N: Endothelial function in patients with sleep APNEA but without hypertension. American Society of Hypertension 19th Annual Scientific Meeting, 18- 22 May, 2004, New York Marriott Marquis, New York, NY, USA. American Journal of Hypertension 17(5):  71A- P108, 2004. 

THIS PAPER IS INDEXED IN SCI.

47. Pamukçu B, Oflaz H, Acar RD, Umman S, Koylan N, Umman B, Nişancı Y. The role of exercise on platelet aggregation in patients with stable coronary artery disease: exercise induces aspirin resistant platelet activation. EUROPEAN HEART JOURNAL 2005, 26(Suppl.1): 255. 

THIS PAPER IS INDEXED IN SCI.

48. İlerigelen, B, Kabakçı, G, Koylan N, Kozan Ö, Büyüköztürk K. Coexisting dyslipidemia in hypertensive patients. ATHEROSCLEROSIS SUPP 6 (1): 156-156 APR 2005

THIS PAPER IS INDEXED IN SCI.

49. Büyüköztürk , K, İlerigelen, B, Kabakçı, G, Koylan N, Kozan Ö. The impact of hs-CRP on risk evaluation in hypertensive patients: Lessons learned from ICEBERG study. ATHEROSCLEROSIS SUPP 2005, 6 (1): 153-154.

THIS PAPER IS INDEXED IN SCI.

50. Kozan O, Koylan N, Büyüköztürk  K, İlerigelen B, Kabakçı G, Kanbolat M, Toker S.  The impact of microalbuminuria and hs-CRP on risk evaluation in people with high-normal and high blood pressure: Results from ICEBERG studyAm J Hypertens 2005, 18(5 Part 2 Suppl. S):: 1A-1A 

THIS PAPER IS INDEXED IN SCI.

51. Büyüköztürk  K, İlerigelen B, Kabakçı G, Kozan O, Koylan N, Kanbolat M, Toker S. The impact of multiple laboratory testing on risk evaluation in people with high-normal and high blood pressure: Results from iceberg study. AMERICAN JOURNAL OF HYPERTENSION 2005, 18(5 Part 2 Suppl. S): 141A-141A. 

THIS PAPER IS INDEXED IN SCI.

52. İlerigelen B, Kabakçı G, Kozan O, Koylan N, Büyüköztürk  K, Kanbolat M, Toker S. The impact of echocardiography and carotid ultrasonography on risk evaluation in people with high-normal and high blood pressure: Results from iceberg study. AMERICAN JOURNAL OF HYPERTENSION  2005, 18(5 Part 2 Suppl. S): 145A-145A. 

THIS PAPER IS INDEXED IN SCI.

53. Koylan N, Büyüköztürk  K, İlerigelen B, Kabakçı G, Kozan O, Kanbolat M, Toker S. The impact of echocardiography on the detection of left ventricular hypertrophy in people with high-normal and high blood pressure: Results from iceberg study. AMERICAN JOURNAL OF HYPERTENSION  2005, 18(5 Part 2 Suppl. S): 145A-146A.

THIS PAPER IS INDEXED IN SCI.

54. Kabakçı G, Koylan N, Büyüköztürk  K, İlerigelen B, Kozan O, Kanbolat M, Toker S. The impact of microalbuminuria measured by qualitative or quantitative methods on risk evaluation in hypertensive patients: Results from iceberg study. AMERICAN JOURNAL OF HYPERTENSION  2005, 18(5 Part 2 Suppl. S): 146A-146A.

THIS PAPER IS INDEXED IN SCI. 

55. İlerigelen B, Kabakçı G, Koylan N, Kozan O, Kanbolat M, Toker S, Büyüköztürk  K. The factors correlated with microalbuminuria in hypertensive patients. European Society of Cardiology Congress 3–7 September 2005, Stockholm – Sweden.  EUROPEAN HEART JOURNAL 2005, 26 (Suppl.1): 168. THIS PAPER IS INDEXED IN SCI.

56. Kabakçı G, Koylan N, Kozan O, İlerigelen B, Büyüköztürk K. Cardiovascular risk classification in hypertensive patients with or without metabolic syndrome: Results from the ICEBERG study. ACC 2006, Atlanta, Georgia, 11-14 March 2006. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2006, 47(4- Suppl. A): 311A-312A. THIS PAPER IS INDEXED IN SCI.

57. Kabakçı, G; İlerigelen, B; Koylan, N, Kozan O, Büyüköztürk , K. Routine assessment of risk factors in hypertensive patients as recommended by ESC/ESH hypertension guidelines: Do physicians ignore the importance of risk factors? JOURNAL OF HYPERTENSION 2008, 26: S300. THIS PAPER IS INDEXED IN SCI.

Turkish publications

Book

1. a) Ekmekçi A, Koylan N: Serum kolinesteraz düzey değişiklikleri. "Digitalis Zehirlenmesi", Ed. N. Akpınar, Ege University Faculty of Medicine Book of the Month, No: 48, Istanbul (page 22- 23).890

b)Koylan N, Ekmekçi A, Canberk A: Digitalis duyarlılığı. "Digitalis Zehirlenmesi", Ed. N. Akpınar, Ege University Faculty of Medicine Book of the Month, No: 48, Istanbul (page 35- 39).

2. Ekmekçi A, Meriç M, Canberk A, Koylan N: Digitalis zehirlenmesi. "Acil Kalb Hastalıklarında Teşhis ve Tedavi", Ed.: K. Işık, Beta Basım ve Dağıtım A. Ş., Klinik Seri: 5, 1986, p.: 251, 264, Istanbul.

3. a) Ekmekçi A, Koylan N: Renal ve diğer nedenlere dayalı hipertansiyonlar ve tedavisi. "Hipertansiyon", Ed. A. Gürçay, Vakur Ltd., Ankara, 1987 (p.:103- 112).

b) Ekmekçi A, Koylan N: Antihipertansif ilaçların kullanımı ve genel tablo. "Hipertansiyon", Ed. A. Gürçay, Vakur Ltd., Ankara, 1987 (p.: 113- 133).

4. a) Koylan N: Egzersiz testi. (p. 990- 992).

b) Koylan N: Ambulatuar EKG ve holter monitor(p. 992- 993).

"Klinik Bilimler- 2", Ed. Kazancıgil A, Gedikoğlu G, Bayraktar K., Kros Reklamcılık ve Matbaacılık, 1991.

5. Koylan N: Kardiyojenik Şok. “Acil Dahiliye”, 4. Edition, Ed. Çalangu S, Güler K. Güzel Sanatlar Matbaası, 1995 (p. 95- 106)..

6. Koylan N: Antihipertansif ilaçların klinik farmakolojik araştırma yöntemleri. “Antihipertansif İlaçların Klinik Farmakolojisi”, Eds. F C Tulunay, H Ergün, Klinik Farmakoloji Derneği Yayını, p. 265.

7. Koylan N: Ateroskleroz ve Koroner kalp hastalığından korunma ile ilgili klinik çalışmalar. “Hiperlipidemi ve Ateroskleroz”, Ed. Tokgözoğlu L, Argos İletişim, 2000, Istanbul.

8. Koylan N: Türk Kardiyoloji Derneği Ulusal Hipertansiyon Tedavi ve Takip Kılavuzu 2000 (Author as a member of the Guideline Preparation Committee.

9. Koylan N: Kalp yetersizliği ve Angiotensin II reseptör Blokerleri. “Angiotensin II ve Angiotensin II antagonistleri”, Ed. K. Büyüköztürk. Print Center, 2001 (p. 75- 88).

10. a) Koylan N: Kalp Yetersizliğinin Farmakolojik Tedavisi: Beta Reseptör Blokerleri.. "Kalp Yetersizliği", Ed. K Büyüköztürk, N Koylan. Üniform Matbaacılık, 2003 (p. 78- 85)

b) Koylan N: Refrakter Kalp Yetersizliği. "Kalp Yetersizliği", Ed. K Büyüköztürk, N Koylan. Üniform Matbaacılık, 2003 (p. 113- 122).

11. Koylan N. Kalp yetersizliğinin tedavisinde angiotensin II reseptör blokerleri. Büyüköztürk K, Koylan N (Eds.): Angiotensin II ve Angiotensin II Antagonistleri (2. Edition). ISBN 975-93605-2-7, Istanbul, 2005 (p.86- 97).

12. a) Koylan N: Kalp ve damar Hastalıklarında fizik muayene (p. 23- 45).

b) Koylan N: Prekordiyum muayenesi, kalp sesleri (p. 46- 51). 

c) Koylan N: Egzersiz testi (p. 102- 114).

d) Koylan N: Ambulatuar EKG (p. 115).

e) Koylan N: Elektrokardiyografi temelli elektrofizyolojik incelemeler (p. 115- 117).

f) Koylan N: Ambulatuar kan basıncı monitorizasyonu (p. 122- 124).

g) Koylan N: Nükleer tıp görüntüleme yöntemleri (p. 141- 149).

"Kalp Hastalıkları- Semiyoloji ve Tanı Yöntemleri", Ed. Meriç M., Istanbul Medikal Yayıncılık, ISBN 978-975- 6395- 98-1, Istanbul, 2007.

13. a) Koylan N: Kalp ve damar Hastalıklarında fizik muayene (p. 188- 215).

b) Koylan N: Prekordiyum muayenesi (p. 216- 222)

c) Koylan N: Kalbin Oskültasyonu (p. 223- 231).

d) Koylan N: Egzersiz testi (p. 275- 285).

e) Koylan N: Ambulatuar EKG takip yöntemleri (p. 286).

f) Koylan N: Elektrokardiyografi temelli elektrofizyolojik incelemeler (p. 287- 289).

g) Koylan N: Ambulatuar kan basıncı monitorizasyonu (p. 298- 301).

h) Koylan N: Nükleer tıp görüntüleme yöntemleri (p. 324- 332).

"İç Hastalıkları (Semiyoloji)", Ed. Kaysı A., Alfa Basım Yayım Dağıtım Ltd. Şti., ISBN 975- 8052- 83-7, Istanbul, 2007.

14. a) Koylan N: Kalp hastasına yaklaşım, kalbin ve dolaşım sisteminin muayenesi (p. 1511-1548).

b) Koylan N: Egzersiz testi (p. 1645- 1654)

c) Koylan N: Elektrokardiyografik temelli elektrofizyolojik incelemeler (p. 1655- 1656).

d) Büyüköztürk K, Koylan N: Hipertansiyon (p. 1865- 1890).

e) Koylan N: Ateroskleroz ve aterosklerotik risk faktörleri (p. 1891- 1914).

"İç Hastalıkları", Ed. Büyüköztürk K, Nobel Tıp Kitabevleri Ltd. Şti., ISBN 978- 975- 420- 581- 7, Istanbul, 2007.

 

Articles

1. Canberk A, Koylan N, Meriç M, Adalet I, Ekmekçi A, Ertem G: Hafif ve orta derecede hipertansiyonun tedavisinde atenolol'ün yeri. Ist. Tıp Fak. Mecm., 47: 506- 514, 1984.

2. Ekmekçi A, Gören T, Meriç M, Koylan N: Supraventriküler taşikardili hastalarda kardiyoversiyonun serum ve hücre içi elektrolit düzeylerine etkisinin araştırılması. Türk. Klin. Tıp Bil. Araşt. Der., 2: 244: 248, 1984.

3. Gürel F, Meriç M, Koylan N, Canberk A, Ekmekçi A: Akut myokard infarktüsü seyrinde ventrikül esnekliğinde gelişen değişikliklerin apekskardiyogram yöntemi ile progressif olarak izlenmesi. İst. Tıp Fak. Mecm., 48: 11- 20, 1985.

4. Balkancı H, Ekmekçi A, Koylan N, Meriç M, Canberk A: Beta adrenoseptör bloker ilaçlardaki ISA aktivitesinin karbonhidrat metabolizması üzerine etkisinin araştırılması. İst. Tıp Fak. Mecm., 48: 189- 197, 1985.

5. Koylan N, Canberk A, Meriç M, Tezer B, Ekmekçi A, Ertem G, Özcan R: Nifedipin'in hipertansiyon tedavisinde birinci basamak ilacı olarak etkinliği. İst. Tıp Fak. Mecm., 48: 208- 216, 1985.

6. Koylan N, Ekmekçi A, Erdemgüler T, Çalangu S, Oral T, Meriç M, Canberk A: Acil hipertansion tedavisinde dilalti nifedipin'in etkinliğinin intravenöz furosemid ile karşılaştırılması. İst. Tıp Fak. Mecm. 48: 394- 402, 1985. 

7. Koylan N, Büyüköztürk K, Meriç M, Nişancı Y, Adalet K, Deligönül U, Güven Ö, Berkmen R: Mitral kapak diastolik açıklık alanının ekokardiografik olarak hesaplanması: Kalb kateterizasyonu ile karşılaştırmalı bir çalışma. İst. Tıp Fak. Mecm., 49: 9- 21, 1986.

8. Güven Ö, Adalet K, Koylan N, Berkmen R, Özkan E, Işık K, Büyüköztürk K, Ertem G, Özcan R: Akut myokard infarktüsü geçiren hastalarda risk faktörleri, lokalizasyon ve komplikasyonların araştırılması. İst. Tıp Fak. Mecm., 49: 185- 193, 1986.

9. Meriç M, Koylan N, Adalet K, Şamilgil Meriç M, Ekmekçi A, Büyüköztürk K, Ertem G: Konjestif kalb yetersizliği tedavisinde prazosin'in klinik kullanımı ile alınan sonuçlar. 9th Congress of Istanbul Medical Faculty,  22- 25 September 1987, Istanbul. Congress Book II, p.:21- 27.

10. Meriç M, Nişancı Y, Adalet K, Koylan N, Korkut F, Yaşa M, Ertem G: Gizli preeksitasyon sendromunun teşhisinde kalbin elektriksel stimulasyonunun önemi: Nodo- ventriküler iletili bir vak'a. 9th Congress of Istanbul Medical Faculty,  22- 25 September 1987, Istanbul. Congress Book II, p.:68- 75.

11. Meriç M, Adalet K, Ertem G, Koylan N, Karabulut N, Arseven A: Esansiyel hipertansiyon tedavisinde labetalol ve propranolol ile karşılaştırmalı bir klinik çalışma. 9th Congress of Istanbul Medical Faculty, 22- 25  September 1987, Istanbul. Congress Book III, p.:170- 181.

12. Ertem G, Akbulut T, Dişçi R, Utku F,Gürbüz Y,Tuncer O, Kütükçüler S, Yolalan ST, Koylan N, Meriç M, Canberk A, Sabuncu H, Adalet K, Okur Ö, Erzengin F, Korkut F, Nişancı Y, Güven Ö,Özsaruhan Ö, Büyüköztürk K, Özkan E, Işık K, Ekmekçi A, Berkmen R, Özcan R: Türkiye’de koroner kalb hastalığı risk faktörlerinin prevalansı. Istanbul Halk Sağlığı Bülteni 1:7, 1987.

13. Kazancıoğlu R, Meriç M, Adalet K, Koylan N, Ekmekçi A, Ertem G, Özcan R: Esansiyel hipertansiyonlu hastalarda nadolol ve pindolol'un plazma lipoproteinlerine olan etkileri: Sempatomimetik aktivitenin önemi. 

a) Klinik Gelişim Dergisi, 1: 261- 267, 1988.

b) Sandoz Ürünleri Ltd. Şti. İlaç Bölümü, 1988, Istanbul.

14. Uslubaş S, Meriç M, Adalet K, Koylan N, Nişancı Y, Büyüköztürk K, Berkmen R, Ertem G, Özkan E: Kronik kor pulmonale'li hastalarda serum lipid seviyelerinin incelenmesi. İst. Tıp Fak. Mecm., 51: 25- 32, 1988.

15. Boztaş G, Adalet K, Ekmekçi A, Meriç M, Koylan N, Korkut F, Canberk A, Ertem G, Özcan R: Esansiyel hipertansiyonlu ailelerin normal tansiyonlu çocuklarında eritrosit içi sıvı volümlerinin araştırılması. İst. Tıp Fak. Mecm., 52: 555- 566, 1989.

16. Meriç M, Nişancı Y, Adalet K, Gören T, Umman S, Atılgan D, Koylan N, Onursal E, Büyüköztürk K, Ertem G: İskemik kalb hastalığında perkütan transluminal koroner anjioplasti tedavisinden elde edilen sonuçlar ve komplikasyonlar. İst Tıp Fak Mecm 53 (3): 1- 14, 1990.

17. Umman S, Atılgan D, Gören T, Nişancı Y, Umman B, Koylan N, Adalet K, Öncül A, Meriç M, Özcan R: Hipertrofik obstrüktif kardiyomyopatide 10 mg sublingual nifedipinin kardiyovaskuler sisteme etkisinin araştırılması- Ekokardiografik bir çalışma. İst Tıp Fak Mecm 53 (4): 1- 10, 1990.

18. Atılgan D, Gören T, Umman S, Koylan N, Adalet K, Meriç M, Nişancı Y, Berkmen R: Nadir bir hipertrofik kardiyomyopati ve homozigot familyer hiperkolesterolemi vakası. İst Tıp Fak Mecm 53 (4): 131- 140, 1990.

19. Meriç M, Nişancı Y, Adalet K, Gören T, Umman S, Atılgan D, Koylan N, Onursal E, Barlas C, Korkut F, Güven Ö, Özsaruhan Ö, Erzengin F, Özcan R, Ertem G, Büyüköztürk K, Berkmen R: İstikrarsız angina pektoris'de perkütan transluminal koroner anjioplastinin yeri. Türk Kardiyol. Dern. Arş. 18: 124- 128, 1990.

20. Meriç M, Nişancı Y, Gören T, Adalet K, Umman S, Atılgan D, Koylan N, Barlas C, Korkut F, Güven Ö, Özcan R, Ertem G, Büyüköztürk K, Berkmen R: Akut romatizmal ateşe bağlı mitral darlığında balonlu kateter ile perkütan transseptal valvuloplastiden elde edilen sonuçlar. Klinik Gelişim 3: 714- 718, 1990.

21. Canberk A, Gönçoğlu H, Koylan N: Esansiyel hipertansiyonlu hastalarda plazma lipid fraksiyonları. Türk Tıp Der Der 56: 312- 317, 1990.

22. Atılgan D, Koylan N, Adalet K,Gören T, Umman S, Meriç M: Kararlı angina pektorisli hastalarda aminofilin’in egzersiz kapasitesi üzerine akut etkisi. Türk Tıp Der Der 9:409- 414, 1990.

23. Nişancı Y, Özsaruhan Ö, Adalet K, Umman S, Meriç M, Atılgan D, Koylan N, Gören T, Ertem G, Özcan R: Antitaşikardik kalb pillerinin uzun süreli takip sonuçları. Türk Kardiyol Dern Arş 19: 54- 57, 1991.

24. Nişancı Y, Deligönül U, Alatlı C, Erbengi T, Umman S, Adalet K, Koylan N, Gören T, Atılgan D, Meriç M, Erseven G, Ertem G: Transvenöz endomyokardial biyopsi sonuçlarımız. Türk Kardiyol Dern Arş 19: 58- 62, 1991.

25. Gören T, Kaymaz C, Nişancı Y, Adalet K, Koylan N, Meriç M: Egzersiz testi sırasında ortaya çıkan ST segment yükselmesinin önemi (bir vaka nedeniyle). Türk Klin Kardiyol 4:145- 148, 1991.

26. Koylan N, Canberk A, Atılgan D, Özbey N, Gören T, Umman S, Büyüköztürk K, Ertem G: Hipertansiyonlu ve normal kişilerde plazma Endotelin- 1 seviyeleri. İst Tıp Fak Mecm 55: 397- 404, 1992.

27. Atılgan D, Koylan N, Umman S, Gören T, Meriç M: Koroner arteriografi sırasında ortaya çıkan ventriküler aritmiler üzerine atropinin etkisi. İst Tıp Fak Mecm 55: 1- 6, 1992.

28. Koylan N, Mercanoğlu F, Orak E, Erzengin F, Büyüköztürk K: Cilazapril'in esansiyel hipertansiyonda sol ventrikül diastolik fonksiyonları üzerine akut etkileri. Türk Klin Kardiyol 7: 17- 20, 1994.

29. Koylan N, Atılgan D, Canberk A, Buğra Z, Ünlüer O, Vural A, Büyüköztürk K: Hafif ve orta derecede esansiyel hipertansiyonlu hastalarda sinyal ortalamalı elektrokardiyogram bulgularının incelenmesi ve geç potansiyel sıklığı. Türk Klin Kardiyol 7(3): 133- 136, 1994.

30. Meriç M, Adalet K, Nişancı Y, Umman S, Koylan N, Gören T, Mercanoğlu F, Buğra Z, Öncül A, Helvacı A, Umman B, Büyüköztürk K, Ertem G: Kronik total koroner arter oklüzyonu tedavisinde konvaniyonel ile magnum magnarail anjioplasti yöntemlerinin karşılaştırılması. Türk Kardiyol Dern Arş 22: 224- 228, 1994.

31. Buğra Z, Koylan N, Okur Ö, Öncül A, Vural A, Ünlüer O, Büyüköztürk K: Sağlıklı erişkinlerde ventriküler geç potansiyeller. Türk Kardiyol Dern Arş 22: 246- 248, 1994.

32. Buğra Z, Meriç M, Koylan N, Adalet K, Nişancı Y, Büyüköztürk K, Ertem G: Koroner anjioplastinin ventriküler geç potansiyeller üzerine uzun süreli etkileri. MN Kardiyoloji 1: 14- 19, 1994.

33. Meriç M, Nişancı Y, Adalet K, Umman S, Gören T, Koylan N, Yılmaz E, Buğra Z, Öncül A, Orak E, Büyüköztürk K, Ertem G: Kombine diyagnostik koroner arteriyografi ve anjiyoplasti ile elektif koroner anjiyoplastinin karşılaştırılması. T Klin Kardiyol 7: 31- 34, 1994.

34. Yılmaz E, Nişancı Y, Meriç M, Yılmaz G, Koylan N,Adalet K, Buğra Z, Büyüköztürk K, Ertem G: Perkütan transluminal koroner anjioplasti uygulanan stabil angina pektorisli hastalarda troponin T düzeyleri. Türk Kardiyol Dern Arş 23: 198- 202, 1995.

35. Adalet I, Adalet K, Heper C, Şirali C, Orak E, Buğra Z, Koylan N, Ertem G, Büyüköztürk K, Cantez S: Esansiyel hipertansiyonlu hastalarda captopril ve benazepril’in sol ventrikül fonksiyonlarına etkilerinin radyonüklid ventrikülografi ile değerlendirilmesi: Çift kör ve karşılaştırmalı bir çalışma. T Klin Kardiyol 8: 72- 77, 1995.

36. Yılmaz E, Ağaçfidan A, Yılmaz G, Umman B, Mercanoğlu F, Koylan N, Adalet K, Öncül A, Badur S, Nişancı Y, Meriç M: Koroner kalb hastalarında chlamydia pneumoniae infeksiyonu yeni bir risk faktörü olabilir mi? T Klin Kardiyol 8: 146- 148, 1995.

37. Koylan N: Hiperkolesterolemi tedavisinde Simvastatin’in etki ve güvenilirliği. MN Kardiyol 3:222- 228.

38. Helvacı A, Meriç M, Koylan N, Erzengin F, Gören T, Umman S, Büyüköztürk K, Ertem G. Mitral Stenozlu Hastalarda Perkütan Mitral Balon Valvotomi Öncesinde ve Sonrasında Sol Atriyal Apendiks Akımlarının İncelenmesi. Türk Kardiyol Dern Arş 1997; 25:0-0

39. Mercanoğlu F, Karşıdağ K, Oflaz H, Alo F, Koylan N, Erzengin F, Büyüköztürk K, Ertem G. Yeni Başlayan Tip II Diabetes Mellituslu, Normotensif Hastalarda Sol Ventrikül Diyastol Fonksiyonları. Türk Kardiyol Dern Arş 1997; 25:0-0.

40. Mercanoğlu F, Oflaz H, Yılmaz E, Umman S, Küçükbasmacı Ö, Koylan N, Büyüköztürk K: Akut myokard infarktüsünün tanısında hızlı, kalitatif troponin T tayininin değeri ve kantitatif troponin T analizi ile karşılaştırılması. Türk Kardiyol Dern Arş 27: 98- 103, 1999.

41. Büyüköztürk K, İlerigelen B, Kabakçı G, Koylan N, Kozan Ö: Türkiye’deki hipertansiyon hastalarının risk profillerinin belirlenmesine yönelik geniş ölçekli bir çalışma: I.C.E.B.E.R.G. Çalışması. Türk Kardiyol Der Arş 32(6): 344- 349, 2004

42. Topbaş A, Bilge AK, Biricik FS, Kocaman O, Oflaz H, Soyluk Ö, Koylan N: Hafif ve orta derecede esansiyel hipertansiyonu olan hastalarda losartan’ın plazma prolaktin, kortizol ve TSH düzeylerine etkisi. İst. Tıp Fak. Mecm. 67(4):224- 228, 2004.

43. Kabakcı G, Koylan N, İlerigelen B, Kozan Ö, Büyüköztürk K. Hipertansif hastalarda dislipideminin kardiyovasküler risk sınıflandırması üzerine etkisi ve lipid profilinin diğer kardiyovasküler risk faktörleriyle ilişkisi: ICEBERG çalışmasından sonuçlar. Türk Kardiyol Dern Arş 2007; 35:458-466

Türkçe derlemeler

1. Koylan N: Diabetik Retinopati. İst. Tıp Fak. Mecm., 4: 242- 250, 1980.

2. Ekmekçi A, Meriç M, Koylan N: Beta adrenoseptör blokerler (Klinik farmakolojisi ve yan etkileri). Türkiye Klinikleri, 2: 9- 18, 1982.

3. Berkmen R, Ekmekçi A, Meriç M, Koylan N: Kalsiyum Antagonistleri. İst. Tıp Fak. Mecm., 46: 164- 172, 1983.

4. Ekmekçi A, Koylan N, Meriç M: Kalsiyum Antagonistleri. Doğu İlaç Fabrikası A. Ş., September 1983, Istanbul.

5. Ekmekçi A, Meriç M, Koylan N: Koroner kalb hastalığında cerrahi tedavinin yeri. Sandoz İlaç Sanayi Ltd. Şti., Orhanlar Matbaası, 1983, Istanbul.

6. Ekmekçi A, Canberk A, Meriç M, Koylan N, Nişancı Y: Hipertansiyonun epidemiyolojisi. Ciba Tıbbi Yayınlar Dizisi, 1984, Istanbul.

7. Ekmekçi A, Canberk A, Meriç M, Koylan N, Nişancı Y: Primer hipertansiyonun patofizyolojisi ve patogenezi. Ciba Tıbbi Yayınlar Dizisi, 1984, Istanbul.

8. Ekmekçi A, Canberk A, Meriç M, Koylan N, Boztaş G: Beta- adrenoseptör blokerlerdeki parsiyel agonist aktivite (ISA) gücünün hemodinamik, metabolik ve klinik önemi. Sandoz İlaç Sanayi Ltd. Şti., Orhanlar Matbaası, 1984, Istanbul.

9. Ekmekçi A, Cantez T, Canberk A, Meriç M, Koylan N: Hipertansiyon tedavisinde diüretiklerin yeri ve sakıncaları. Servier- Ali Raif İlaç Sanayii, 1984, Istanbul.

10. Ekmekçi A, Cantez T, Canberk A, Meriç M, Koylan N, Tezer B: Hipertansiyonda vazodilatasyon tedavisi ve alfa- adrenoseptör blokerlerin yeri. Pfizer Araştırmalar Dizisi 1, 1985, Istanbul.

11. Koylan N, Meriç M, Atılgan D: Nitrat tedavisinde yeni bir seçenek: Mononitratlar. İst Tıp Fak Mecm 53: 163- 168, 1990 .

12. Meriç M, Koylan N: Diüretikler ve hipertansiyon tedavisinde kullanılmaları. Türk Tıp Der Der 56: 97- 102, 1990.

13. Meriç M, Koylan N: Kalsiyum antagonistleri. Türk Tıp Der Der 56: 124- 131, 1990.

14. Meriç M, Koylan N, Şamilgil Meriç M: Perkütan transluminal aterektomi. İst Tıp Fak Mecm 54: 331- 336, 1991.

15. Kaymaz C, Koylan N, Meriç M: Reperfüzyon hasarı. İst Tıp Fak Mecm 54: 507- 512, 1991.

16. Koylan N: Hipertansiyon, ateroskleroz, hiperinsulinemi ve sendrom X. Medikal Magazin 92: 45- 46, 1993.

17. Mercanoğlu F, Koylan N: İskemik kalb hastalığı tedavisinde farklı bir mekanizma- K+ kanal aktivasyonu ve nicorandil. Türk Kard Dern Arş 22: 43- 48, 1994.

18. Kaymaz C, Koylan N: Kalb hızı değişkenliği (Heart rate variability). İst Tıp Fak Mecm 57: 111-114, 1994.

19. Buğra Z, Koylan N: Kalb yetersizliğinin takip ve tedavisinde egzersiz testinin değeri. Türk Klin Kardiyol 7: 55- 57, 1994.

20. Umman B, Koylan N: Hipertansiyon tedavisinde yeni bir adım: Angiotensin II antagonistleri. Türk Klin Kardiyol 9: 118- 122, 1996.

21. Umman B, Koylan N: Oksijen serbest radikalleri ve kardiyolojide klinik önemleri. İst Tıp Fak Mecm (in-print).

22. Umman B, Koylan N: Hipertansiyonda metabolik boyut. Hipokrat 51: 10- 16, 1996.

23. Umman B, Koylan N: Hipertansiyon ve sol ventrikül hipertrofisi. Hipokrat 51: 17- 23, 1996.

24. Koylan N: Aterosklerozda yeni risk faktörleri: Düşük HDL, hipertrigliseridemi ve hiperhomosisteinemi. Hipokrat Kardiyoloji 1(4): 23- 28, 1997.

25. Umman B, Koylan N: Angiotensin II reseptörleri ve antagonistleri. AII Konseyi Bülteni 1(1): 3, 1997.

26. Koylan N, Mercanoğlu F: Hipertansiyon tedavisinde kalsiyum antagonistlerinin yeri. Hipokrat 71: 7-11, 1998.

27. Koylan N: Lipoprotein (a) ve sırları. British Medical Journal 4(4): 8- 9, 1999.

28. Koylan N: Lipoprotein (a) ve ateroskleroz. Türk Kardiyoloji Derneği Arşivi, 27(8): 483- 490, 1999.

29. Mercanoğlu F, Koylan N: Kalp yetersizliğinde nörohumoral mekanizmalar. AII Konseyi Bülteni 3(1): 58- 60, 1999.

30. Koylan N: Esansiyel hipertansiyon ve hücre membranı. Folia 1(1): 17- 22, 2000.

31. Koylan N: Ateroskleroz ve koroner kalp hastalığından korunma ile ilgili klinik çalışmalar. Türkiye Tıp Dergisi 7(1): 40- 47, 2000.

32. Koylan N: Koroner kalp hastalığı epidemiyolojisi, lipid düşürücü tedavi ile ilgili büyük klinik çalışmalar. Türkiye Klinikleri Kardiyoloji, 13(1- Suppl. 1): 9- 20, 2000.

33. Koylan N: Ateroskleroz ve koroner kalp hastalığından korunma ile ilgili büyük klinik çalışmalar. Türkiye Klinikleri Kardiyoloji, 13(1- Suppl. 1): 21- 21- 28, 2000.

34. Koylan N: İskemik kalp hastalığı tanısında egzersiz testi ve benzerleri ile uygulanan nükleer kardiyolojik tanı yöntemleri. Hipokrat Kardiyoloji 4(13): 8- 17, 2000.

35. Koylan N: Sildenafil ve Kardiyovaskuler sistem. Androloji Bülteni 3: 4-5, 2000.

36. Koylan N: Akut myokard infarktüsü sonrası risk belirlenmesi ve kronik koroner kalp hastalığının tedavisine bireysel yaklaşım. Türkiye Klinikleri Kardiyoloji 13 (4- Ek 1): 23- 30, 2000.

37. Koylan N: Hipertansiyon ve endotel. Türkiye Klinikleri Kardiyoloji 13 (5): 333- 336, 2000.

38. Koylan N: Kılavuz kurallar eşliğinde hipertansiyonda bireysel risk belirlenmesi. AII Konseyi Bülteni 4(1): 8- 10, 2000.

39. Koylan N: Türk toplumu ve koroner kalp hastalığı trendindeki artış. Türk Kardiyoloji Derneği Arşivi. 29:610-611, 2001.

40. Koylan N: Diabet ve hipertansiyon. Avicena 2(9): 6-11, 2001.

41. Koylan N: Hipertansiyon ve kognitif fonksiyon. AII Konseyi Bülteni 5(1): 11- 13, 2001.

42. Koylan N: Hipertansiyon ve ACE inhibitörleri, Türk Kardiyoloji Seminerleri 2(2):165- 174, 2002.

43. Koylan N: Kardiyovaskuler Hastalıklar ve Diyet. Actual Medicine 10(3): 40-46, 2002.

44. Koylan N: Klinik araştırmalar ve klinik kanıtlar. AII Konseyi Bülteni 6(1): 7-9, 2002.

45. Koylan N: Klinik araştırmalar ve kanıta dayalı Tıp terminolojisi. AII Konseyi Bülteni 6(2): 28- 30, 2002.

46. Koylan N: Hipertansiyon tedavisinde hedefler ve LIFE çalışması. AII Konseyi Bülteni 6(3): 37- 40, 2002.

47. Koylan N: Evde kan basınc takibi. AII Konseyi Bülteni 7(3):38- 44, 2003.

48. Mercanoğlu F, Koylan N: Kalp dışı cerrahi öncesi kardiyoloji konsultasyonu. Kardiyaktuel 1(1): 8- 12, 2003.

49. Koylan N: Angiotensin II ve ateroskleroz. Kardiyaktuel 1(3): 14- 19, 2003.

50. Koylan N: Atrial fibrilasyon ve hipertansiyon. AII Konseyi Bülteni 8(1): 1- 5, 2004.

51. Koylan N: Diabet, hipertansiyon ve kardiyovaskuler risk. Diabet Forumu 1(1-2): 29- 34, 2004.

52. Koylan N: Diabet, hipertansiyon ve kardiyovaskuler risk. AII Konseyi Bülteni 8(2): 17- 22, 2004.

53. Koylan N: Anjiyotensin II ve Kardiyovaskuler Sistem. Türk Kardiyoloji Seminerleri 4(3): 264- 272, 2004.

54. Koylan N: Refrakter kalp yetersizliği. Türkiye Klinikleri J Cardiol.17(2): 89- 96, 2004.

55. Koylan N: Kardiyovaskuler bir risk faktörü olarak izole sistolik hipertansiyon. AII Konseyi Bülteni 6(3): 34- 38, 2004.

Turkish Academic Papers

1. Ekmekçi A, Meriç M, Koylan N: Kalsiyum Antagonistleri. Gevher Nesibe Science Week and Medicine Days, 11- 13 March 1982, Kayseri. Proceedings, p.: 732- 748.

2. Berkmen R, Ekmekçi A,  Meriç M, Koylan N: Kalsiyum Antagonistleri. Turkish Society of Cardiology  IIIrd Post-Graduation Training Course, 19- 22 April 1982, Istanbul.

3. Özcan M, Ekmekçi A, Koylan N, Meriç M, Özcan R, Berkmen R, Büyüköztürk K, Ertem G, Işık K: Aspirinin düzenli giden serum digoxin düzeylerine etkisi. IIIrd National Cardiology Congress, 24- 27 October 1982, Ankara. Abstract Book, p.: 123.

4. Gürel F, Koylan N, Meriç M, Nişancı Y, Orhan Y, Deligönül U, Ekmekçi A, Büyüköztürk K, Ertem G, Berkmen R, Işık K, Özkan E, Özcan R: Akut myokard infarktüsü seyrinde ventrikül komplians değişikliklerinin apekskardiyogram ile izlenmesi. 7th Congress of Istanbul Medical Faculty, Free Papers of the Congress, 25- 29 September 1983, Istanbul. Abstract Book, p.: 91, Paper no: 161.

5. Yalçın F, Koylan N, Meriç M, Deligönül U, Nişancı Y, Ekmekçi A, Büyüköztürk K, Ertem G, Berkmen R, Işık K, Özkan E, Özcan R: Akut myokard infarktüsünde ventrikül performansında gelişen değişikliklerin apekskardiyogram ile incelenmesi. 7th Congress of Istanbul Medical Faculty, Free Papers of the Congress, 25- 29 September 1983, Istanbul. Abstract Book, p.: 92, Paper no: 163.

6. Özbek H, Koylan N, Meriç M, Nişancı Y, Deligönül U, Ekmekçi A, Büyüköztürk K, Ertem G, Berkmen R, Işık K, Özkan E, Özcan R: Genç yaş myokard infarktüslerinde eritrosit membran ATPase aktivitelerinin araştırılması. 7th Congress of Istanbul Medical Faculty, Free Papers of the Congress, 25- 29 September 1983, Istanbul. Abstract Book, p.: 93, Paper no: 164.

7. Güven Ö, Koylan N, Meriç M, Nişancı Y, Deligönül U, Ekmekçi A, Büyüköztürk K, Ertem G, Berkmen R, Işık K, Özkan E, Özcan R: Aspirinin düzenli giden serum digoxin düzeyine etkisi. 7th Congress of Istanbul Medical Faculty, Free Papers of the Congress, 25- 29 September 1983, Istanbul. Abstract Book, p.: 93, Paper no: 165.

8. Ferhanoğlu B, Koylan N, Meriç M, Canberk A, Nişancı Y, Ekmekçi A, Deligönül U, Büyüköztürk K, Berkmen R, Ertem G, Işık K, Özkan E, Özcan R: Esansiyel hipertansiyonda eritrosit sıvı hacmindeki değişiklikler. 7th Congress of Istanbul Medical Faculty, Free Papers of the Congress, 25- 29 September 1983, Istanbul. Abstract Book, p.: 94, Paper no: 166.

9. Gören T, Koylan N, Nişancı Y, Meriç M, Deligönül U, Ekmekçi A, Büyüköztürk K, Berkmen R, Ertem G, Işık K, Özkan E, Özcan R: Supraventriküler taşikardili hastalarda kardiyoversiyonun serum ve hücre içi elektrolit düzeylerine etkisi. 7th Congress of Istanbul Medical Faculty, Free Papers of the Congress, 25- 29 September 1983, Istanbul. Abstract Book, p.: 96, Paper no: 169.

10. Canberk A, Meriç M, Koylan N, Ertem G, Ekmekçi A: Primer hipertansiyon, patofizyoloji ve patogenez, tedavisinde kullanılan ilaçlar ve tedavi prensipleri.7th Congress of Istanbul Medical Faculty, Symposium on New Developments in the Treatment of Cardiovascular Diseases, 25- 29 September 1983, Istanbul. Symposium Book, p.: 91- 94.

11. Uluğlar L, Sandalcı Ö, Ekmekçi A, Azizlerli H, Meriç M, Alagöl F, Koylan N, Berker F: Supraventriküler taşikardili hastalarda kardiyoversiyonun serum prolaktin, büyüme hormonu ve kortizol düzeylerine etkisi. IV. National Cardiology Congress, October 9- 12, 1984, Izmir. Abstract Book, p.: 16.

12. Koylan N, Canberk A, Tezer B, Ekmekçi A, Ertem G, Özcan R: Beta blokerler ve indapamid'in kombine edilmesi ile elde edilen antihipertansif etkinin incelenmesi. IV. National Cardiology Congress, October 9- 12, 1984, Izmir. Abstract Book, p.: 38.

13. Koylan N, Canberk A, Tezer B, Adalet I, Meriç M, Ekmekçi A, Ertem G: Pindolol- nifedipin kombinasyonunun antihipertansif etkinliğinin araştırılması. IV. National Cardiology Congress, October 9- 12, 1984, Izmir. Abstract Book, p.: 40.

14. Canberk A, Koylan N, Meriç M, Adalet I, Ekmekçi A, Koyuncuoğlu H, Ertem G: Hafif ve orta derecede hipertansiyonun tedavisinde atenolol'un yeri. IV. National Cardiology Congress, October 9- 12, 1984, Izmir. Abstract Book, p.: 41.

15. Koylan N, Canberk A, Meriç M, Ekmekçi A, Ertem G, Özcan R: Esansiyel hipertansiyonlu hastalarda oxprenolol retard uygulamasının antihipertansif etkisinin araştırılması. IV. National Cardiology Congress, October 9- 12, 1984, Izmir. Abstract Book, p.: 42.

16. Özkan E, Koylan N, Öner A, Çakaloğlu Y, Meriç M, Korkut F, Büyüköztürk K: Atenolol'un hemostaz üzerine olan etkilerinin trombin ve parsiyel tromboplastin zamanları aracılığı ile araştırılması. IV. National Cardiology Congress, October 9- 12, 1984, Izmir. Abstract Book, p.: 90.

17. Balkancı H, Koylan N, Meriç M, Canberk A, Ekmekçi A: Beta- adrenoseptör bloker ilaçlardaki ISA aktivitesinin karbonhidrat metabolizması üzerine etkisinin araştırılması. IV. National Cardiology Congress, October 9- 12, 1984, Izmir. Abstract Book, p.: 91.

18. Koylan N, Canberk A, Meriç M, Tezer B, Ekmekçi A, Ertem G, Özcan R: Nifedipin'in hipertansiyon tedavisinde birinci basamak ilacı olarak etkinliği. IV. National Cardiology Congress, October 9- 12, 1984, Izmir. Abstract Book, p.: 93.

19. Özkan E, Koylan N: İskemik kalb hastalığında cerrahi tedavinin yeri ve önemi. Bezm-i Alem Valide Sultan Vakıf Gureba Hospital 3rd Prof. E. Frank Memorial Day Panels- Panel on the Current Status of Coronary Surgery, 13 February 1985, Istanbul. Panel Book p.: 37- 45.

20. Canberk A, Erbengi T, Canberk Y, Ertem G, Tezer B, Koylan N: Primer hipertansiyonlu hastaların eritrositlerinin ultrastrüktürel olarak incelenmesi. 8th Congress of Istanbul Medical Faculty, Congress on Electronmicroscopy, 16- 20 September 1985, Istanbul. Congress Book p.: 68.

21. Güven Ö, Koylan N, Özkan E, Büyüköztürk K, Ertem G, Berkmen R, Işık K, Özsaruhan Ö, Özcan R: Akut myokard infarktüsü geçiren hastalarda risk faktörleri, lokalizasyon ve komplikasyonların araştırılması. 8th Congress of Istanbul Medical Faculty, Congress on Emergency Medicine, 16- 20 September 1985, Istanbul. Congress Book p.: 287.

22. Güven Ö, Koylan N, Özkan E, Berkmen R, Işık K, Büyüköztürk K, Ertem G, Özcan R: Akut myokard infarktüsü seyrinde ortaya çıkan intraventriküler ileti bozukluklarının sıklığı ve infarktüs lokalizasyonu ile ilişkisi. 8th Congress of Istanbul Medical Faculty, Congress on Emergency Medicine, 16- 20 September 1985, Istanbul. Congress Book p.: 288.

23. Koylan N, Güven Ö, Okur Ö, Özkan E, Büyüköztürk K, Ertem G, Işık K, Berkmen R, Özcan R: Akut myokard infarktüsü seyrinde ortaya çıkan atrioventriküler ileti bozukluklarının sıklığı ve infarktüs lokalizasyonu ile ilişkisi. 8th Congress of Istanbul Medical Faculty, Congress on Emergency Medicine, 16- 20 September 1985, Istanbul. Congress Book p.: 289.

24. Koylan N, Güven Ö, Okur Ö, Özkan E, Büyüköztürk K, Berkmen R, Ertem G, Işık K, Özsaruhan Ö, Özcan R: Akut myokard infarktüslü hastalarda erken dönem mortalitenin çeşitli faktörlerle ilişkisi. 8th Congress of Istanbul Medical Faculty, Congress on Emergency Medicine, 16- 20 September 1985, Istanbul. Congress Book p.: 290.

25. Koylan N, Ekmekçi A, Erdemgüler T, Çalangu S, Oral T, Oral T, Meriç M, Canberk A: Acil hipertansiyon vak'alarında dilaltı verilen nifedipin'in etkinliğinin intravenöz furosemid ile karşılaştırılması. 8th Congress of Istanbul Medical Faculty, Congress on Emergency Medicine, 16- 20 September 1985, Istanbul. Congress Book p.: 291.

26. Güven Ö, Koylan N, Berkmen R, Ertem G, Büyüköztürk K, Işık K, Özkan E, Özcan R: Morfinin koroner sinüs kan akımı ve koroner direnç üzerine olan etkilerinin araştırılması. 1985 Cardiology Meeting co-organised by the Turkish Society of Cardiology and Dicle University, 9- 12 October 1985, Diyarbakır. Türk Kardiyoloji Derneği Arşivi, Issue: 14, p.: 13, 1986.

27. Levi S, Büyüköztürk K, Meriç M, Koylan N, Erzengin F, Özsaruhan Ö, Özkan E, Özcan R: Esansiyel hipertansiyonda verapamil'in akut etkilerinin kansız yöntemlerle araştırılması.V. National Cardiology Congress, 5- 8 November 1986, Istanbul. Abstract Book, p.: 16- 17.

28. Güven Ö, Adalet K, Koylan N, Berkmen R, Özkan E,  Işık K, Büyüköztürk K, Ertem G, Özsaruhan Ö, Özcan R: Akut myokard infarktüsü geçiren hastalarda risk faktörleri, lokalizasyon ve komplikasyonların araştırılması. Vth National Cardiology Congress, 5- 8 November 1986, Istanbul. Abstract Book, p.: 23- 24.

29. Seyithanoğlu BY, Ekmekçi A, Meriç M, Adalet K, Koylan N, Korkut F, Ertem G, Özcan R: Akut myokard infarktüsünden sonra hastane içi prognozun belirlenmesinde serum F/ FDP oranının yeri ve önemi. Vth National Cardiology Congress, 5- 8 November 1986, Istanbul. Abstract Book, p.: 24- 25.

30. Koylan N, Büyüköztürk K, Meriç M, Deligönül U, Nişancı Y, Erzengin F, Güven Ö, Berkmen R: Saf mitral darlığında mitral kapağın diastolik açıklık alanının M- mode ekokardiyografi ile hesaplanması ve hemodinamik bulgularla karşılaştırılması. Vth National Cardiology Congress, 5- 8 November 1986, Istanbul. Abstract Book, p.: 44- 45.

31. Uslubaş S, Özkan E, Meriç M, Adalet K, Koylan N, Nişancı Y, Büyüköztürk K, Berkmen R, Ertem G, Özcan R: Kronik kor pulmonale'li hastalarda serum lipid seviyelerinin incelenmesi. Vth National Cardiology Congress, 5- 8 November 1986, Istanbul. Abstract Book, p.: 60.

32. Ertem G, Akbulut T, Dişçi R, Utku T, Gürbüz Y, Tuncer O F, Kütükçüler N, Yolalan S T, Koylan N, Meriç M, Canberk A, Sabuncu H, Adalet K, Okur Ö, Erzengin F, Korkut F, Nişancı Y, Güven Ö, Özsaruhan Ö, Büyüköztürk K, Özkan E, Berkmen R, Ekmekçi A, Özcan R: Türkiyede koroner kalb hastalığı risk faktörleri prevalansı. I- Hipertansiyon- Çalışanlarda kan basıncı taraması. Vth National Cardiology Congress, 5- 8 November 1986, Istanbul. Abstract Book, p.: 65.

33. Kazancıoğlu R, Ekmekçi A, Meriç M, Adalet K, Koylan N, Korkut F, Canberk A, Ertem G, Özcan R: Esansiyel hipertansiyonda beta- blokerlerin plazma lipid fraksiyonlarına etkileri ve ISA'nın önemi. Vth National Cardiology Congress, 5- 8 November 1986, Istanbul. Abstract Book, p.: 90- 91.

34. Boztaş G, Ekmekçi A, Meriç M, Adalet K, Koylan N, Korkut F, Canberk A, Ertem G, Özcan R: Primer hipertansiyonlu ailelerin normal tansiyonlu çocuklarında eritrosit içi sıvı volümlerinin araştırılması. Vth National Cardiology Congress, 5- 8 November 1986, Istanbul. Abstract Book, p.: 91.

35. Meriç M, Adalet K, Ertem G, Koylan N, Karabulut N, Arseven A: Esansiyel hipertansiyon tedavisinde labetalol ve propranolol ile karşılaştırmalı klinik bir çalışma. 9th Congress of Istanbul Medical Faculty,  22- 25 September 1987, Istanbul. 

36. Meriç M, Nişancı Y, Adalet K, Koylan N, Korkut F, Yaşa M, Ertem G: Gizli preeksitasyon sendromunun teşhisinde kalbin elektriksel stimulasyonunun önemi: Nodo- ventriküler iletili bir vak’a. 9th Congress of Istanbul Medical Faculty,  22- 25 September 1987, Istanbul.

37. Meriç M, Koylan N, Adalet K, Şamilgil M, Ekmekçi A, Büyüköztürk K, Ertem G: Konjestif kalb yetersizliği tedavisinde prazosin’in klinik kullanımı ile alınan sonuçlar. 9th Congress of Istanbul Medical Faculty,  22- 25 September 1987, Istanbul.

38. Erzengin F, İnanç M, Büyüköztürk K, Adalet K, Umman S, Atılgan D, Gören T, Koylan N, Nişancı Y, İnanç S, Öncül A: Duvar disseksiyonu gösteren ilginç bir sol ventrikül anevrizması vakası. VIIth National Cardiology Congress, 26- 30 May 1990, Izmir. Türk Kardiyol Dern Arş VIIth VIIth National Cardiology Congress Paper Abstracts Issue, Paper no: 205.

39. Umman S, Nişancı Y, Özsaruhan Ö, Adalet K, Kargı A, Gören T, Koylan N, Güven Ö, Barlas C: Konjestif kalb yetersizliğine sebep olan iki ilginç arteriovenöz fistül vakası. VIIth National Cardiology Congress, 26- 30 May 1990, Izmir. Türk Kardiyol Dern Arş VIIth VIIth National Cardiology Congress Paper Abstracts Issue, Paper no: 238.

40. Adalet K, Meriç M, Nişancı Y, Onursal E, Gören T, Koylan N, Özcan R, Ertem G, Büyüköztürk K, Berkmen R: İstikrarsız ("Unstable") angina pektoris'de perkütan transluminal koroner anjioplasti. VIIth National Cardiology Congress, 26- 30 May 1990, Izmir. Türk Kardiyol Dern Arş VIIth VIIth National Cardiology Congress Paper Abstracts Issue, Paper no: 300.

41. Canberk A, Koylan N, Yıldıran G, Ertem G, Özcan R, Ekmekçi A: Esansiyel hipertansiyon tedavisinde enalapril. 1st National Hypertension Congress and ACE Inhibitors Symposium with International Participation, 10- 12 October 1990, Adana. Congress Book p.: 38.

42. Yılmaz E, Adalet K, Yılmaz G, Badur S, Erzengin F, Koylan N, Özsaruhan Ö, Çetin ET, Büyüköztürk K: Koroner kalb hastalığında serum antikardiolipin seviyelerinin önemi: Preliminer bir çalışma.

a)1991 Cardiology Meeting, 10- 13 September 1991, Trabzon. Türk Kardiyol Dern Arş 1991 Cardiology Meeting Paper Abstracts Issue, Paper no: 39.

b)11th Congress of Istanbul Medical Faculty,  22- 25 September 1991, Istanbul. Abst. Book, p. 85.

43. Koylan N, Canberk A, Atılgan D, Özbey N, Gören T, Umman S, Büyüköztürk K, Ertem G: Sağlıklı kişilerde ve hipertansiyonlularda plazma endotelin- 1 düzeyleri. 

a)1991 Cardiology Meeting, 10- 13 September 1991, Trabzon. Türk Kardiyol Dern Arş 1991 Cardiology Meeting Paper Abstracts Issue, Paper no: 68.

b)11th Congress of Istanbul Medical Faculty,  22- 25 September 1991, Istanbul. Abst. Book, p. 83.

44. Adalet K, Koylan N, Atılgan D, Adalet I, Erzengin F, Ertem G, Büyüköztürk K: Stabil angina pektoriste oral gallopamil ve nifedipine 'in etkilerinin karşılaştırılması- Plasebo kontrollü, çift kör, randomize, çapraz bir çalışma.

a)1991 Cardiology Meeting, 10- 13 September 1991, Trabzon. Türk Kardiyol Dern Arş 1991 Cardiology Meeting Paper Abstracts Issue, Paper no: 149.

b)11th Congress of Istanbul Medical Faculty,  22- 25 September 1991, Istanbul. Abst. Book, p. 84.

45. Erzengin F, Büyüköztürk K, Umman S, Buğra Z, Öncül A, Adalet K, Koylan N, Ertem G: Sol ventrikül diyastolik fonksiyonlarının Eko- Doppler yöntemi ile tetkiki ve hemodinami bulguları ile kıyaslanması.

a)1991 Cardiology Meeting, 10- 13 September 1991, Trabzon. Türk Kardiyol Dern Arş 1991 Cardiology Meeting Paper Abstracts Issue, Paper no: 222.

b)11th Congress of Istanbul Medical Faculty,  22- 25 September 1991, Istanbul. Abst. Book, p. 82.

46. Adalet K, Koylan N, Buğra Z, Umman B, Öncül A, Ertem G: Hafif yada orta derecede esansiyel hipertansiyonlu hastalarda uzun etkili bir kalsiyum antagonisti olan felodipin'in etkinliği: Tek kör, plasebo kontrollü bir çalışma. 11th Congress of Istanbul Medical Faculty,  22- 25 September 1991, Istanbul. Abst. Book, p. 87.

47. Adalet I, Özbey N, Adalet K, Buğra Z, Koylan N, Erzengin F, Meriç M, Nişancı Y, Özsaruhan Ö, Cantez S, Görpe A, Büyüköztürk K, Ertem G: Akut anterior transmural myokard infarktüsü seyrinde fonksiyonel sol ventrikül anevrizması gelişiminin noninvaziv metodlarla değerlendirilmesi. IInd National Echocardiography Congress, 8- 10 October 1991, Antalya. Abstracts Book, Paper No: O28.

48. Tutar A, Gören T, Nişancı Y, Umman S, Yılmaz E, Umman B, Kaymaz C, Erzengin F, Adalet K, Koylan N, Meriç M, Büyüköztürk K, Ertem G: Mitral stenozu vakalarında kalb hızının Doppler ölçümleri üzerine olan etkisi: Transösefagial "atrial pacing" ile yapılan bir çalışma. IInd National Echocardiography Congress, 8- 10 October 1991, Antalya. Abstracts Book, Paper No: O66.

49. Adalet K, Kaymaz C, Deymeer F, Koylan N, Erzengin F, Özdemir C, Büyüköztürk K, Ertem G: Duchenne Muskuler Distrofi'li hastalarda kardiyovaskuler anormalliklerin ekokardiografik olarak belirlenmesi. IInd National Echocardiography Congress, 8- 10 October 1991, Antalya. Abstracts Book, Paper No: O67.

50. Özbey N, Adalet K, Adalet I, Koylan N, Erzengin F, Ertem G, Büyüköztürk K: Akut myokard infarktüsü seyrinde gelişen tehlikeli ventriküler aritmilerin ventriküler geç potansiyeller ile ilişkisi. VIIIth National Cardiology Congress, 27 September - 1 October 1992, Istanbul. Abstract book p.: 32.

51. Gören T, Atılgan D, Umman S, Eren N, Çubukçu A, Koylan N, Meriç M: Hafif ve orta derecede esansiyel hipertansiyonlu hastalarda uzun süreli isradipine tedavisinin kardiyak ve sistemik etkileri.  VIIIth National Cardiology Congress, 27 September - 1 October 1992, Istanbul. Abstract book p.: 48.

52. Meriç M, Adalet K, Nişancı Y, Umman S, Koylan N, Gören T, Büyüköztürk K, Ertem G: Koroner aterektomi sonuçları (7 hasta nedeniyle). VIIIth National Cardiology Congress, 27 September - 1 October 1992, Istanbul. Abstract book p.: 51.

53. Kaymaz C, Nişancı Y, Umman S, Gören T, Öncül A, Helvacı A, Erzengin F, Koylan N, Meriç M, Özsaruhan Ö, Büyüköztürk K, Ertem G: Primer mitral prolapsusu vakalarında geç potansiyel varlığı ve mitral yetersizliği derecesi ile ilişkisi. VIIIth National Cardiology Congress, 27 September - 1 October 1992, Istanbul. Abstract book p.: 69, Paper no: 300.

54. Umman B, Meriç M, Umman S, Koylan N, Adalet K, Nişancı Y, Ertem G: Ön duvar myokard infarktüsü sonrası angina pektoris bulunan hastalarda sol ön inen arter lezyonuna uygulanan koroner anjioplastinin sol ventrikül global ve bölgesel fonksiyonlarına etkisi. IXth National Cardiology Congress, 28 September - 1 October 1993, Bursa. Abstract book p.: 17, Paper no: 61.

55. Meriç M, Nişancı Y, Adalet K, Umman S, Gören T, Koylan N, Orak E, Buğra Z, Yılmaz E, Büyüköztürk K, Ertem G: Kombine diagnostik koroner arteriografi ve anjioplasti ile elektif koroner anjioplastinin karşılaştırılması. IXth National Cardiology Congress, 28 September - 1 October 1993, Bursa. Abstract book p.: 31, Paper no: 135.

56. Meriç M, Adalet K, Nişancı Y, Umman S, Koylan N, Gören T, Helvacı A, Mercanoğlu F, Umman B, Büyüköztürk K, Ertem G: Total koroner arter oklüzyonu tedavisinde konvansiyonel yöntem ve magnum magnarail sistemi ile anjioplastinin karşılaştırılması. IXth National Cardiology Congress, 28 September - 1 October 1993, Bursa. Abstract book p.: 31, Paper no: 136.

57. Çefle K, Adalet K, Koylan N, Okur Ö, Orak E, Helvacı A, Mercanoğlu F, Meriç M, Ertem G, Büyüköztürk K: Propafenone'un ventriküler aritmiler ve sinyal ortalamalı EKG parametreleri üzerindeki etkisinin araştırılması. IXth National Cardiology Congress, 28 September - 1 October 1993, Bursa. Abstract book p.: 36, Paper no: 159.

58. Buğra Z, Meriç M, Koylan N, Adalet K, Nişancı Y, Büyüköztürk K, Ertem G: Koroner anjioplastinin sinyal ortalamalı elektrokardiograma uzun süreli etkileri. IXth National Cardiology Congress, 28 September - 1 October 1993, Bursa. Abstract book p.: 37, Paper no: 161.

59. Helvacı A, Adalet K, Meriç M, Orak E, Buğra Z, Yılmaz E, Nişancı Y, Koylan N, Umman S, Gören T, Büyüköztürk K, Ertem G: Hipertansiyonlu iskemik kalb hastalarında koroner angiografi ile birlikte selektif renal angiografi uygulanmasının önemi. IXth National Cardiology Congress, 28 September - 1 October 1993, Bursa. Abstract book p.: 64, Paper no: 263.

60. Erzengin F, Mercanoğlu F, Eren N, Orak E, Gören T, Koylan N, Umman B, Öncül A, Büyüköztürk K, Ertem G: Hipertrofik kalb hastalığında yeni ekokardiografik tanı kriterleri. IIIrd National Echocardiography Congress, 10- 12 May 1994, Antalya. Abstracts Book, Paper No: 090.

61. Buğra Z, Meriç M, Koylan N, Adalet K, Nişancı Y, Büyüköztürk K, Ertem G: Koroner anjioplastinin sinyal ortalamalı EKG'ye uzun süreli etkileri. IInd National Invasive Cardiology Congress, 23-24 June 1994, Izmir.  Abstract book p.48.

62. Koylan N, Atılgan D, Canberk A, Buğra Z, Ünlüer O, Vural A, Büyüköztürk K: Hafif ve orta derecede esansiyel hipertansiyonlu hastalarda sinyal ortalamalı EKG sonuçları. Xth National Cardiology Congress, October 1- 4, 1994, Izmir. Abstract Book, paper no: 40.

63. Koylan N, Altuğ T, Atılgan D, Canberk A, Büyüköztürk K: Hafif ve orta derecede esansiyel hipertansiyonlu hastalarda hücre içi serbest oksijen radikalleri ve sinyal ortalamalı EKG: Ön sonuçlar. Xth National Cardiology Congress, October 1- 4, 1994, Izmir. Abstract Book, paper no: 41.

64. Yılmaz E, Nişancı Y, Meriç M, Yılmaz G, Koylan N, Adalet K, Umman S, Gören T, Buğra Z, Öncül A, Büyüköztürk K, Ertem G: Perkütan transluminal koroner anjioplasti uygulanan stabil angina pektorisli hastalarda troponin T düzeylerinin klinik önemi (preliminer bir çalışma). Xth National Cardiology Congress, October 1- 4, 1994, Izmir. Abstract Book, paper no: 110.

65. Adalet I, Adalet K, Heper C, Şirali M, Orak E, Buğra Z, Umman B, Koylan N, Cantez S, Büyüköztürk K: Esansiyel hipertansiyonlu hastalarda captopril ve benazepril’in sol ventrikül fonksiyonlarına etkilerinin radyonüklid ventrikülografi ile değerlendirilmesi: Çift kör ve karşılaştırmalı bir çalışma. Xth National Cardiology Congress, October 1- 4, 1994, Izmir. Abstract Book, paper no: 118.

66. Koylan N, Canberk A, Gülbaba G, Mercanoğlu F: Esansiyel hipertansiyonlu hastalarda nitrendipin'in plazma endotelin-I düzeylerine etkisi. Xth National Cardiology Congress, October 1- 4, 1994, Izmir. Abstract Book, paper no: 133.

67. Öncül A, Özsaruhan Ö, Umman S, Nişancı Y, Erzengin F, Koylan N, Meriç M, Büyüköztürk K, Ertem G: İki odacıklı iki sensörlü pacemaker implante edilmiş hastalarda “sensor blending” ve “sensor cross- checking” ile elde edilen kalp hızlarının normallerle kıyaslanması. Xth National Cardiology Congress, October 1- 4, 1994, Izmir. Abstract Book, paper no: 157.

68. Öncül A, Özsaruhan Ö, Umman S, Nişancı Y, Adalet K, Koylan N, Umman B, Erzengin F, Meriç M, Büyüköztürk K, Ertem G: Çok sensörlü iki odacıklı pacemakerlerde günlük olağan aktiviteler sırasında “sensor blending” ve “sensor cross- checking”in yararları. Xth National Cardiology Congress, October 1- 4, 1994, Izmir. Abstract Book, paper no: 158.

69. Koylan N, Okur Ö, Buğra Z, Vural A, Ünlüer O, Büyüköztürk K: Sağlıklı kişilerde sinyal ortalamalı EKG parametrelerinde değişkenlik. Xth National Cardiology Congress, October 1- 4, 1994, Izmir. Abstract Book, paper no: 166.

70. Adalet K, Nalbantgil İ, Kılıççıoğlu B, Koylan N, Buğra Z, Umman B, Adalet I, Erzengin F, Büyüköztürk K: Hafif ya da orta derecede esansiyel hipertansiyonlu hastalarda benazepril ve captopril’in etkileri: Çok merkezli, çift kör ve karşılaştırmalı bir çalışma. Xth National Cardiology Congress, October 1- 4, 1994, Izmir. Abstract Book, paper no: 207.

71. Canberk A, Koylan N, Berkman K, Pakhoo M. Akut hipertansiyon ataklarında dilaltı nitrendipin etkinliği. Xth National Cardiology Congress, October 1- 4, 1994, Izmir. Abstract Book, paper no: 251.

72. Koylan N, Altuğ T, Güzel Ö, Öncül A, Mercanoğlu F, Gündoğdu R, Ertem G: Koroner kalb hastalığı olan kişilerde lipoprotein(a) ve diğer plazma lipid fraksiyonları. Xth National Cardiology Congress, October 1- 4, 1994, Izmir. Abstract Book, paper no: 270.

73. Koylan N, Pakhoo M, Sezer A, Buğra Z, Mercanoğlu F, Meriç M, Büyüköztürk K: Egzersiz testinin değerlendirilmesinde ST- kalb hızı analizinin önemi. XIth National Cardiology Congress, 23- 26 September 1995, Istanbul. Abstract book, paper no: 254.

74. Yılmaz E, Ağaçfidan A, Yılmaz G, Umman B, Mercanoğlu F, Koylan N, Adalet K, Öncül A, Nişancı Y, Meriç M, Büyüköztürk K, Ertem G: Chlamydia pneumoniae infeksiyonu ve koroner kalb hastalığı: Aralarında bir ilişki olabilir mi?. XIth National Cardiology Congress, 23- 26 September 1995, Istanbul. Abstract book, paper no: 331.

75. Koylan N, Buğra Z, Vural A, Sezer A, Mercanoğlu F, Meriç M, Büyüköztürk K: Hafif- orta derecede hipertansiyonu olan hastalarda nisoldipine’in sol ventrikül diastolik fonksiyonu ve QT dağılımına akut etkileri. 

a) XIth National Cardiology Congress, 23- 26 September 1995, Istanbul. Abstract book, paper no: 366.

b) Çukurova University 2nd National Hypertension Congress with International Participation, 19- 21 October 1995, Adana. Congress Book p.28.

76. Canberk A, Delier H, Berkman K, Yıldıran G, Koylan N, Büyüköztürk K, Ertem G, Koyuncuoğlu H: Esansiyel hipertansiyon olgularında verapamil ile trandolapril kombinasyonu. Çukurova University 2nd National Hypertension Congress with International Participation, 19- 21 October 1995, Adana. Congress Book p.43.

77. Buğra Z, Koylan N, Vural A, Umman B, Mercanoğlu F, Meriç M, Büyüköztürk K, Ertem G: Hafif- orta dereceli hipertansiyonu olan, tedavi görmemiş hastalarda, sol ventrikülün geometrik şekillenmesinin ve hipertrofisinin tipleri ve QT dağılımı. Turkish Society of Cardiology XIIth National Cardiology Congress, Belek, Antalya, 16-20 October, 1996. Abstract Book No 93.

78. Helvacı A, Meriç M, Erzengin F, Koylan N, Gören T, Umman S, Büyüköztürk K, Ertem G: Mitral stenozlu hastalarda perkütan mitral balon valvotomi öncesinde ve sonrasında sol atriyal apendiks akımlarının incelenmesi. Turkish Society of Cardiology XIIth National Cardiology Congress, Belek, Antalya, 16-20 October, 1996. Abstract Book No: 281.

79. Mercanoğlu F, Oflaz H, Adalet K, Karşıdağ K, Alo F, Erzengin F, Koylan N, Büyüköztürk K, Ertem G: Yeni başlayan tip II diabetes mellituslu normotensif hastalarda sol ventrikül diastolik fonksiyonlarının değerlendirilmesi. Turkish Society of Cardiology XIIth National Cardiology Congress, Belek, Antalya, 16-20 October, 1996. Abstract Book No: 284.

80. İsbir T, Ağaçkakan B, Yılmaz H, Oflaz H, Koylan N: Aterosklerozlu ve sağlıklı bireylerde ACE gen polimorfizminin incelenmesi. Turkish Society of Cardiology XIIIth National Cardiology Congress, Izmir, 29 September- 3 October 1997. Abstract Book No: 49.

81. Mercanoğlu F, Oflaz H, Nişancı Y, Umman B, Gören T, Meriç M, Erzengin F, Koylan N, Ertem G, Büyüköztürk K: Trombolitik tedavi uygulanan akut myokard infarktüslü hastalarda infarktüs ile ilgili arter açıklığının erken komplikasyonlar, sol ventrikül fonksiyonları ve revaskularizasyon girişimi üzerine etkisi. Turkish Society of Cardiology XIIIth National Cardiology Congress, Izmir, 29 September- 3 October 1997. Abstract Book No: 100.

82. Mercanoğlu F, Oflaz H, Yılmaz E, Umman B, Gören T, Koylan N, Büyüköztürk K: Hasta başında hızlı kalitatif troponin- t tayininin akut myokard infarktüsünün tanısındaki değeri. Turkish Society of Cardiology XIIIth National Cardiology Congress, Izmir, 29 September- 3 October 1997. Abstract Book No: 188.

83. Oflaz H, Buğra Z, Sezer A, Özaydın M, Koylan N, Büyüköztürk K: Sağlıklı erişkinlerde diürnal ritmin sinyal ortalamalı EKG üzerine etkisi. Turkish Society of Cardiology XIIIth National Cardiology Congress, Izmir, 29 September- 3 October 1997. Abstract Book No: 329.

84. Yılmaz H, Oflaz H, İsbir T, Koylan N: Ateroskleroz tanısı konmuş olgularda serum apolipoprotein A1, B ve lipoprotein düzeyleri. Turkish Society of Cardiology XIIIth National Cardiology Congress, Izmir, 29 September- 3 October 1997. Abstract Book No: 395.

85. Koylan N, Taşköprü İ,Karşıdağ K, Oflaz H, Büyüköztürk K: İnsuline bağımlı olmayan diabetes mellituslu hastalarda otonom diyabetik nöropatinin tesbitinde yeni bir yöntem olarak QT dispersiyonu. XIVth National Cardiology Congress, 10-13 October 1998, Belek, Antalya. Paper no: 114.

86. Mercanoğlu F, Oflaz H, Yılmaz E, Umman S, Umman B, Küçükbasmacı Ö, Gören T, Koylan N, Büyüköztürk K: Akut myokard infarktüsünün tanısında kalitatif ve kantitatif troponin T analizlerinin karşılaştırılması. XIVth National Cardiology Congress, 10-13 October 1998, Belek, Antalya. Paper no: 166.

87. Koylan N, Pakhoo M, İspir T, Özbek H, Atılgan D, Meriç M, Büyüköztürk K: Hafif ve orta şiddette esansiyel hipertansiyonlu hastalarda perindopril’in eritrosit membran ATPase değerleri üzerine etkisi. XIVth National Cardiology Congress, 10-13 October 1998, Belek, Antalya. Paper no: 217.

88. Atılgan D, Koylan N, Akkaya V, Özbek H, Meriç M, Büyüköztürk K: Atrial fibrilasyonu olmayan mitral stenozunun sol atrial apendiks fonksiyonları üzerine zarar verici etkisi var mı? Transözfajiyal ekokardiyografik bir çalışma. XIVth National Cardiology Congress, 10-13 October 1998, Belek, Antalya. Paper no: 297.

89. Koylan N, Büyüköztürk K: Koroner kalp hastalığı olan hastalarda trimetazidine ve diltiazem’in egzersiz performansı üzerine olan etkilerinin karşılaştırılması. Türk Trimetazidine Çalışması. XIVth National Cardiology Congress, 10-13 October 1998, Belek, Antalya. Paper no: 396.

90. Topbaş A, Koylan N, Oflaz H, Özaydın M, Özsaruhan Ö, Erzengin F: Hafif ve orta derecede hipertansiyonu olan hastalarda losartan’ın plazma prolaktin, kortizol ve TSH düzeylerine etkisi. XVth National Cardiology Congress, 9- 12 October 1999, Büyük Efes and Hilton Hotels, Izmir. Subject no: 305.

91. Tayyareci Y, Koylan N, Öncül A, Nisancı Y, Umman B, Altun İ, Yurdakul S, Buğra Z. Sistemik hipertansiyonlu hastalarda insülin direnci varlığı sol ventrikül sistolik fonsksiyonlarını doku düzeyinde olumsuz etkilemektedir. XXIIIrd National Cardiology Congress, 21- 24 October 2007, Antalya. Türk Kardiyol Dern Arş 2007, Suppl 2.

92. Tayyareci Y, Beyhan S, Koylan N, Nişancı Y, Öncül A, Altun İ, Adalet K, Buğra Z. Kronik alkol kullanımı olan hastalarda insülin direnci ve GGT düzeyinin QT dispersiyonuna etkisi. XXIIIrd National Cardiology Congress, 21- 24 October 2007, Antalya. Türk Kardiyol Dern Arş 2007, Suppl 2.

93. Tayyareci Y, Buğra Z, Koylan N, Öncül A, Umman B, Altun İ, Yurdakul S, Adalet K, Nişancı Y. Prehipertansiyonlu olgularda da sol ventrikül longitudinal fonksiyonları ve kontraktilitesi doku düzeyinde bozulmuştur. XXIIIrd National Cardiology Congress, 21- 24 October 2007, Antalya. Türk Kardiyol Dern Arş 2007, Suppl 2.

 

Projects with International Acronyms

1. National Coordinator of HEAAL study, 2003-2009

2. ICEBERG Epidemiological Study Board Member, 2003- 2004

3. SAGE Study International Board Member, 1999- 2004

4. VALUE Study International Board Member and National Coordinator, 1998- 2005

5. ELITE II Study (published), 1996- 2000

6. TTS Study (published), 1990- 1996

Areas of Interest

What is Good for Low Blood Pressure? Symptoms of Low Blood Pressure

Blood pressure is an indicator that measures the resistance created by the blood pumped by the heart in the blood vessels. There are two different values for this pressure: systolic and diastolic. Systolic pressure, also known as high blood pressure, measures the blood pressure during the heart's contraction. Diastolic pressure, known as low blood pressure, refers to the measurement of blood pressure during the heart's resting phase. Low blood pressure is a health issue characterized by blood pressure being lower than the normal range. For healthy individuals, the ideal blood pressure is expressed as 120/80. Here, the value of 120 indicates systolic pressure, while the value of 80 refers to diastolic blood pressure. Low blood pressure is characterized by blood pressure values lower than 90/60. In some cases, low blood pressure may indicate a serious health problem. Especially in older individuals, low blood pressure can obstruct sufficient blood flow to the heart, brain, and other vital organs. This can lead to symptoms such as dizziness, fainting, and shock. Causes of low blood pressure may include dehydration, pregnancy, heart disorders, nervous system diseases, and certain medications. To prevent and treat low blood pressure, lifestyle changes such as drinking adequate amounts of water, increasing salt intake, rising slowly from a seated position, avoiding caffeine, eating low-carbohydrate meals, exercising the leg muscles, and wearing compression stockings can be applied. In some cases, medication treatment may also be recommended by a doctor.

What is Marfan Syndrome, Its Symptoms, Causes, and Treatment

Marfan syndrome is a rare disease that primarily occurs due to genetic reasons and affects connective tissue. Connective tissue is an important structure that forms the supportive tissue in the body and holds organs together. Marfan syndrome arises from a mutation in the FBN1 gene, which encodes the protein fibrillin-1. This mutation can affect the elasticity and durability of connective tissue, leading to a range of systemic issues. Individuals with Marfan syndrome are typically tall, slender, and have long limbs. One of the most commonly affected areas is the cardiovascular system, where aneurysms and heart valve problems are frequently observed. Additionally, noticeable features may be present in the eyes, skeleton, and skin. The treatment of Marfan syndrome is prepared with input from multiple specialties, aiming to improve the patient's quality of life and manage symptoms

Heart Attack Symptoms in Women are Different

What is Heparin and What Does it Do?

Heparin is used in the treatment and prevention of many health issues such as vascular blockages, heart attacks, and strokes by preventing blood clotting. By regulating blood flow and preventing blockages, heparin use helps avoid the formation of clots. However, there are several factors to consider for the effective and safe administration of heparin treatment. Key points that should be addressed for the success of heparin therapy include correct dosage, drug interactions, and nutrition. Additionally, factors such as the patient's medical history, age, and gender play a significant role in personalizing the treatment.

What is a Murmur? How is Murmur Treatment Done?

A murmur is the general term for sounds heard during a heart examination with a stethoscope, in addition to normal heart sounds, that resemble a blowing or whooshing sound.

What is Blood Pressure? Symptoms of High and Low Blood Pressure

The heart continuously pumps blood to the body through the aorta. During this pumping process, the blood is sent through the vessels under pressure. The pressure that forms on the inner walls of the blood vessels is defined as blood pressure. Blood pressure, which can also be referred to as arterial pressure, is crucial for the adequate supply of blood to tissues and organs, enabling them to carry out vital functions. Each time the heart contracts, it pumps blood into the arteries with a certain pressure, and when the heart muscle relaxes, some pressure remains in the vessels. These two types of pressure are referred to as systolic and diastolic blood pressure. Although blood pressure can vary from person to person, the average range is expected to be 90 to 120 mm Hg for systolic blood pressure and 60 to 80 mm Hg for diastolic blood pressure. Low blood pressure, known as hypotension, usually does not pose a significant risk and rarely leads to symptomatic problems. However, a sudden drop in blood pressure can cause symptoms such as headaches and fatigue. High blood pressure, known as hypertension, is much more serious than low blood pressure and can lead to severe health problems. Before delving into the types of blood pressure, it is important to understand what blood pressure means.

What is Pulse? What Should the Ideal Pulse Rate Be?

Measuring the pulse shows how fast the heart is beating. A normal pulse beats at a regular rhythm, and its normal values can vary depending on certain factors. If the heart beats too slowly or too quickly, it may be a sign of a heart condition. Pulse measurement provides important results for detecting such problems. The pulse can be measured, particularly at the wrist.

Symptoms and Treatment Methods of Rheumatic Heart Disease (Acute Rheumatic Fever)

Acute rheumatic fever, commonly known as rheumatic heart disease, is a rheumatic condition that develops after a throat infection (pharyngitis) caused by bacteria known as group A streptococci. It typically appears 2 to 3 weeks after the pharyngitis. The disease results in inflammatory damage in organs containing connective tissue due to an abnormal inflammatory response from the body.

Thickening of the Heart Muscle

Although not widely known among the public, this is a very serious and important issue. It is defined as an increase in the mass of the heart muscle or thickening due to the accumulation of other tissues and substances within the heart muscle.

Thickening of the Heart Muscle and Hypertension

Thickening of the heart muscle is defined as an increase in the mass of the heart muscle or thickening due to the accumulation of other tissues and substances within the heart muscle. According to Cardiology Specialists at Anadolu Medical Center, the main cause of this condition, which can lead to heart failure, is hypertension. They provide insights into heart muscle thickening.

Heart Palpitations: What They Are, Causes, Symptoms, and Treatment

Heart palpitations are among the top reasons for visits to emergency rooms and cardiology clinics. The term "heart palpitations" refers to the sensation of an accelerated heartbeat, an irregular heartbeat, or a change in rhythm. Due to these changes in how the heart functions, a person may feel as if something is pounding strongly in their neck or chest. While the underlying causes of heart palpitations are generally benign, it’s important to note that, in some cases, they can be due to life-threatening conditions, so caution is necessary.

Capillary Leak Syndrome: What It Is, Causes, Symptoms, and Treatment

Capillary Leak Syndrome, known medically as Systemic Capillary Leak Syndrome (SCLS), was first described in 1960 by Dr. Bayard Clarkson, which is why it is also referred to as Clarkson’s disease. This syndrome can have a severe course due to the shock state that develops during its progression, making awareness of the condition crucial.

Hypertension: What It Is, Symptoms, and Treatment

A person's blood pressure is the force exerted by blood against the walls of arteries as it circulates through the body. Blood pressure is measured in two parts: the systolic blood pressure, commonly known as "high" blood pressure, and diastolic blood pressure, known as "low" blood pressure. The unit of blood pressure is millimeters of mercury (mmHg). Systolic blood pressure measures the maximum pressure in the arteries when the heart contracts to pump blood. Diastolic blood pressure reflects the minimum pressure in the arteries when the heart rests between beats.

Hypertension Disease

Blood pressure values above 40/90 mmHg are considered hypertension. Hypertension is a disease that leads to complications such as heart attack, stroke, heart failure, and kidney failure, and it shortens life expectancy in both men and women.

What Causes Chest Pain?

Chest pain, which can range from a dull, tight sensation to a sharp, stabbing pain, may sometimes radiate to the arm and neck. The causes of chest pain can be symptoms of various diseases. In serious problems related to the heart and lungs, the exact cause of chest pain should be determined, and immediate medical intervention is required

Angiography is not a treatment, but a diagnostic method

Angiography, which is still considered the gold standard for imaging the heart's blood vessels, plays a very important role in the diagnosis and treatment of cardiovascular diseases. Anadolu Health Center cardiology specialists emphasize that angiography is a diagnostic method aimed at revealing the narrowing or blockage of coronary vessels to determine the treatment approach. They answer questions you may have regarding angiography…

What Causes Vomiting? What Helps with Vomiting?

Vomiting is a digestive system disorder that results in the involuntary expulsion of stomach contents. It is usually preceded by a feeling of nausea and can be a symptom of many pathological conditions. Causes include infections, head injuries, cancer treatments, certain medications, poisoning, medical procedures, and illnesses. After vomiting, it's crucial to ensure adequate hydration due to excessive loss of water and electrolytes from the body. Some methods can be used to prevent vomiting when feeling nauseous, and after vomiting, certain practices can help compensate for the losses and damage in the body. To minimize the effects on the body, consuming tolerable amounts of water after vomiting is important. If vomiting is frequent and persistent, consulting a specialist healthcare provider is essential.

What Are the Symptoms of Anemia? What Relieves Anemia?

Anemia is a blood disease caused by insufficient levels of red blood cells in the blood. Anemia is also known as a deficiency in red blood cells and hemoglobin and can result from multiple factors. When anemia develops, a person may experience symptoms such as shortness of breath, fatigue, weakness, pale skin, and cold hands and feet. Anemia typically arises from nutritional deficiencies. Therefore, doctors often prescribe vitamin supplements and provide dietary recommendations. These dietary recommendations are based on consuming foods rich in iron, folate, vitamins B12 and C. If you think you are at risk of anemia, you should consult a doctor.

What Helps with Fatigue? How to Overcome Fatigue?

The complaint of fatigue can also be expressed as tiredness and exhaustion. All healthy individuals can experience fatigue when they engage in heavy tasks or do not eat adequately. This condition is usually temporary, and the person will regain their previous health over time. However, in some cases, these complaints can manifest as symptoms of chronic autoimmune diseases. Since prolonged fatigue may indicate a different illness, it should not be ignored, and seeing a doctor for examination can lead to an early diagnosis. Obesity and excess weight can restrict a person's movements, leading to fatigue over time. Additionally, individuals with below-normal weight may experience fatigue due to nutritional deficiencies. A proper diet that meets vitamin and mineral needs, along with an exercise routine suitable for the individual's age and health, can help alleviate fatigue problems. Paying attention to the consumption of grains, fresh fruits, protein sources, and healthy fats can contribute to feeling energetic. Changes in sleep patterns, restricting the intake of excessively fatty and sugary foods can help ensure a more energetic day. The amount of water consumed throughout the day should be maintained at levels that meet the body's needs, and if possible, mineral-enhanced waters should be preferred. Individuals experiencing issues such as stress and depression may face fatigue problems. Seeking psychological support for such issues can help alleviate their effects over time.

What is Raynaud's Syndrome?

Raynaud's syndrome develops as a result of the contraction of blood vessels, leading to episodes in the extremities and is characterized by the interruption of blood flow. In Raynaud's syndrome, which generally requires the use of vasodilator medications for treatment, blood flow to structures such as the fingers or toes, ears, and nose can be disrupted. This condition, which occurs in episodes, is defined as vasospasm. Raynaud's syndrome is classified into two groups: primary (or idiopathic) and secondary. In primary Raynaud's syndrome, there is no underlying condition causing the episodes, whereas in the secondary form, attacks can occur due to conditions such as arthritis, frostbite, or various autoimmune diseases. You can follow the continuation of the text for more information about other topics related to Raynaud's syndrome.

What is Cat Allergy? Causes, Symptoms, and Treatment

Cat allergy is a hypersensitivity to a cat's saliva, fur, skin dander, or urine. These substances, which trigger allergic reactions, are known as allergens. Cat allergy can range from mild respiratory symptoms, such as sneezing and runny nose, to severe allergic reactions, including anaphylaxis. If you suspect a cat allergy, it’s essential to consult a doctor for symptom management and an appropriate treatment plan.

Night Sweats

Individuals experiencing night sweats may find that their sheets or pajamas are soaked with water upon waking. Regulating the sleeping environment through various methods is the first step that can be taken to address this issue. In cases where night sweats occur due to an underlying medical condition, it is essential to consult healthcare providers for the identification of the underlying disorder and to consider appropriate treatment options. This condition, referred to as sleep hyperhidrosis, usually arises from manageable diseases, but it can also occur as a sign of life-threatening conditions, making it beneficial to be informed. You can follow the continuation of this article for more information on other topics related to night sweats.

Spleen Enlargement

Causes and Treatment of Muscle Wasting in Old Age

As people age, the frequency of muscle wasting increases, with Prof. Dr. Çağatay Öktenli, an Internal Medicine Specialist at Anadolu Health Center, noting that 4 out of every 10 people over the age of 80 face this issue.

Mosquito Bites (Itching): Causes, Remedies, and Prevention

Mosquitoes are delicate creatures with small, short lifespans, long legs, and distinctive wings, easily recognizable. Typically appearing during summer nights, they are known for the itchy bumps they leave after biting. These noticeable itchy bumps are allergic reactions caused by a chemical mosquitoes use when they extract blood. The mosquitoes that feed on blood are usually females, as they require the proteins found in human or animal blood for reproduction. Male mosquitoes, on the other hand, feed on flower nectar and plant juices. A mosquito bite usually subsides within 24 hours and doesn’t cause serious problems, but it should be monitored for allergic reactions. In endemic regions, mosquitoes can transmit serious diseases like malaria, West Nile virus, dengue, filariasis, yellow fever, and Zika virus.

Gallbladder Diseases: Symptoms, Diagnosis, and Treatment Methods

The human digestive system consists of two main parts: the organs within the digestive tract and the accessory digestive organs. The digestive tract—comprising the mouth, esophagus, stomach, small intestine, large intestine, and anus—plays a major role in digestion. For effective mechanical and chemical digestion of food, absorption of nutrients in the small intestine, calorie supply for cells, and elimination of waste through defecation, both the organs of the digestive tract and accessory structures such as the liver, pancreas, and gallbladder must work together in harmony.

Norovirus: What It Is, Symptoms, Diagnosis, and Treatment

Stomach Pain: What Is It, Symptoms, Causes, and How to Relieve It?

Stomach pain is a common condition experienced by both children and adults. There can be numerous different causes of stomach pain. What causes stomach pain? What helps relieve it? You can find the answers to all these questions in the following text.

Creatinine: What is Its High and Low Levels and Their Treatment

Creatinine is a compound found in the bloodstream of every individual, released as a result of metabolic processes. Creatinine is excreted from the body through the urinary tract and should be present in specific levels within the body. The amount of creatinine that should be present in a person's bloodstream varies according to age, gender, race, and body measurements. However, having creatinine levels outside of these parameters can be indicative of certain diseases. In particular, creatinine levels can be evaluated to determine whether kidney functions are operating healthily.

Cortisol: What It Is, Treatment Methods, and Side Effects

Cortisol is a hormone-like substance naturally synthesized in the human body. There may be diseases associated with its deficiency. Some patients may not synthesize sufficient amounts of cortisol in their bodies. Complete lack of cortisol synthesis is not possible in a healthy body. For these patients, cortisol replacement therapy, which has offered very effective solutions in recent years, is applied. This is because the effects of cortisol are undeniably important for the immune system and the body's ability to heal itself. In cases where it is not produced, exogenous synthetic hormones, meaning cortisol obtained from external sources, should be administered. The synthetic form of cortisol that cannot be synthesized in the body is called cortisone. There may be misconceptions in the public about the use of cortisol and cortisone, leading to the belief that cortisol has more negative effects. Of course, while cortisol treatment has negative effects, it also provides significant treatment opportunities for the patient. Every medication can have side effects, even if they are minor. The effects of cortisol treatment can be managed as long as doctor visits are not neglected and post-treatment recommendations are followed. Cortisol is a hormone produced in the outer part of the adrenal gland called the cortex. One of the naturally occurring hormones formed as a result of a series of biochemical reactions using cholesterol as a raw material is cortisol. Two different groups of hormones are produced by the adrenal gland: glucocorticoids and mineralocorticoids. In the glucocorticoid group, there are hormone-like products known as cortisol and cortisone. Both glucocorticoids, cortisol and cortisone, affect the body’s protein and carbohydrate mechanisms. Cortisone is actually the inactive form of cortisol. After its production, cortisone is processed in the liver to obtain the active form, cortisol. Therefore, the active form of cortisol is administered for the treatment of many diseases.

Calcium: What It Is, Its Deficiency and Symptoms, Treatment of Deficiency

Calcium is an essential mineral with important functions that cannot be synthesized by the body and must be obtained through diet. Calcium is directly related to growth, development, the nervous system, the circulatory system, and bone health. Therefore, calcium deficiency can lead to some serious symptoms.

What Is Hiccups, Why Do They Occur, and How to Get Rid of Them?

The diaphragm is the muscle that separates the chest from the abdominal cavity and plays a crucial role in breathing. A spasm of this muscle causes the vocal cords to close temporarily, resulting in the "hic" sound. Hiccups are uncontrolled, repetitive spasms or sudden movements of the diaphragm. Eating too much, drinking alcoholic or carbonated beverages, or sudden excitement can lead to hiccups. For most people, hiccups typically last only a few minutes and resolve on their own.

Hepatitis C Vaccine

The Hepatitis C Vaccine is designed to combat Hepatitis C, a type of liver disease caused by the HCV virus. The Hepatitis C virus can cause chronic infection in the liver, potentially leading to permanent and life-threatening effects on the body. Millions of people around the world are infected with Hepatitis C, with nearly 1 million individuals in our country alone. Although this disease is currently treatable, it often becomes chronic due to late diagnosis in many cases. If diagnosed early without leading to other complications, complete recovery can be achieved.

What is Gout Disease? What Are Its Symptoms and Treatment Methods?

Historically known as the disease of kings, gout disease is characterized by an increase in uric acid circulating in the blood, leading to arthritis, or joint disease. The symptoms of gout develop based on the accumulation of uric acid crystals in the joints and the body’s reaction to them. Gout attacks typically occur at night without any prior warning. Many gout patients recover by paying attention to their diet and lifestyle, while some require medical treatment.

What is Glutathione, Its Benefits, and Treatments?

With glutathione therapy, the antioxidant capacity of our body is increased, making us more resistant to diseases.

What Helps with Food Poisoning? Symptoms and Treatment

Food poisoning can be briefly defined as conditions that are transmitted through food and primarily negatively affect the stomach and intestinal systems. Chemical substances, natural food toxins, metals, pesticides, plastics, detergents, parasites, bacteria, mold, and microorganisms like yeast can all be factors that cause food poisoning. Although the symptoms of food poisoning can vary from person to person, stomach discomfort, diarrhea, and vomiting are often common symptoms. To prevent food poisoning, attention should be paid to hygiene conditions. Discarding moldy foods, thoroughly cleaning kitchen utensils, and washing fruits and vegetables before consumption can be considered preventive measures. Appropriate treatments can be applied to affected individuals based on the severity of the symptoms and the factors causing the poisoning. Treatments can include fluid replacement, probiotics, antibiotics, and antiparasitic medications.

Leaky Gut Syndrome: What Is It, What Are Its Symptoms, and How Is It Diagnosed and Treated?

The healthy concentration of microorganisms in the gut, known as the microbiota, is an extremely valuable structure that directly or indirectly affects the functioning of all body systems, especially the digestive system. The microbiota, which is sterile until birth, begins to develop with birth and is largely influenced by the method of birth, dietary habits, and environmental factors. This microorganism concentration has a very delicate balance, which can be disrupted by unnecessary antibiotic use or unhealthy eating habits such as fast food, leading to an increase in harmful microorganisms, particularly on the intestinal surface. This disrupts the healthy structure of the gut and can lead to various diseases, including leaky gut syndrome.

What is FibroScan?

The liver is the largest organ in the body and is considered the metabolic factory of the body. It is located in the upper right part of the abdominal cavity, beneath the diaphragm, and is responsible for the synthesis of many substances. Chronic liver diseases are one of today's significant health issues. In the advanced stages of chronic liver diseases, liver cells become damaged and swollen (ballooned). As the disease progresses, scar tissue forms in the liver, which is defined as fibrosis.

What is Dehydration, and How Can It Be Prevented?

During the summer months, when temperatures and humidity levels rise, the need for fluids is higher compared to other seasons. The body breathes faster, sweats, and expels excess heat through urine to maintain its temperature against the heat. Approximately 65% of the human body is made up of water. An adult loses an average of 2.5 liters of fluid daily. In addition to fluid loss, minerals such as sodium, calcium, and potassium that regulate the body’s electrolyte balance are also expelled. Under normal conditions, the body can compensate for lost fluids and electrolytes through food and water intake. Reductions in the total fluid amount in the body manifest as feelings of thirst. If fluid loss increases, serious health problems can occur.

Vitamin D: What Is It, What Are Its Deficiencies, Symptoms, and Treatments?

Vitamin D deficiency is a significantly common condition in our country. To prevent issues related to vitamin D deficiency, society needs to be aware of its importance. Eating a healthy diet and getting enough sunlight are crucial in preventing vitamin D deficiency.

What is Celiac Disease?

Celiac disease is an immune system disorder characterized by chronic damage to various tissues on the intestinal surface, caused by both environmental and genetic factors. For genetically susceptible individuals, consuming certain grains like barley, wheat, and rye triggers a reaction in the body, and the protein called gluten found in these grains is perceived as a completely toxic substance by the immune system. Initially considered a gastrointestinal disease, this condition has been extensively studied in recent years, revealing that it significantly affects many systems, including neurological, psychological, hormonal, rheumatological, and cardiological systems. Lack of information regarding celiac disease can delay its diagnosis, which can particularly lead to growth and developmental delays during childhood. Therefore, having accurate knowledge about celiac disease and gluten intolerance is extremely important to support a healthy developmental process.

Sputum: What It Is, Diagnosis, and Treatment

Sputum is a mucus layer that serves a protective lining. The mucus layer found in the respiratory tract prevents the area from drying out and becoming irritated. It acts as a protective structure against foreign substances such as dust and pollen that enter the body. The mucus layer changes in color and structure for various reasons, forming sputum. Generally benign, sputum can sometimes indicate a different health issue. In cases of respiratory and lung diseases, sputum production may increase due to irritation and infection. Therefore, sputum can provide preliminary information about health status. Additionally, home conditions, work environments, and habits can directly or indirectly influence sputum formation. Although producing sputum is seen as the body's way of cleansing itself, it is beneficial to monitor it closely. If there are changes in color, structure, or habit, the underlying cause should be investigated.

How is an Allergy Test Performed?

The immune system protects the body from foreign and harmful substances that enter through the nose, intestines, respiratory system, and skin. In some cases, the immune system's reactions to these foreign and harmful substances may be excessive. This condition is defined as an allergy. Although the exact causes of allergies, which may have a genetic predisposition, are not fully understood, certain allergens play a significant role in the development of the disease. Allergens are grouped into five main categories: environmental allergens (house dust mites, mold spores, pollens, animal allergens), insect allergens, food allergens, drug allergens, and occupational allergens.

What is Mediterranean Fever (FMF Disease)? What Are the Symptoms of FMF?

Familial Mediterranean Fever (FMF) is a genetic disease primarily seen in Mediterranean countries. It is commonly found among Jews of Eastern European descent, Sephardic Jews, Spaniards, Greeks, Armenians, Arabs, and Turks. Although there is an ethnic predisposition, this disease can also affect other populations. The severity of lifelong FMF varies from person to person. Despite being known as Mediterranean Fever, it is more prevalent in the Central Anatolia region in our country.

Aphthous Ulcers: What Are They, Symptoms, Diagnosis, and Treatment

Aphthous ulcers, also known as canker sores, are small, shallow lesions that appear on the soft tissues inside the mouth or at the base of the gums. These sores can sometimes cause intense pain and difficulty with eating and speaking. Unlike cold sores, aphthous ulcers do not appear on the lips and are not contagious. Most aphthous ulcers heal on their own within one or two weeks. However, ulcers that continue to grow without healing may pose health risks, and it is essential to have these evaluated by a doctor.

What is a Hemogram (Complete Blood Count)?

In today's world, blood tests are the first assessment method for detecting most diseases. A complete blood count (CBC), or hemogram test, is performed on a large number of patients daily in hospitals, providing important information for both diagnosis and monitoring. The interpretation of blood tests by specialists, along with the patient's medical history and consideration of other diseases, guides the treatment the doctor will administer. The hemogram test compares the normal range of cell groups in the blood to the patient's cell count. Diseases can be diagnosed by identifying abnormal cells or an increased number of these cells in certain pathological conditions. By analyzing a few milliliters of blood from the patient, a laboratory can provide valuable information that guides treatment decisions

What is Hypothermia? Symptoms and Treatment of Hypothermia

Hypothermia is characterized by a drop in body temperature below 35°C and is a condition that requires emergency medical intervention. The severity of hypothermia can vary. As the severity increases, the risk of death and coma also rises, while the body develops responses to protect itself in the early stages. Therefore, proper first aid methods should be applied until medical intervention can be provided. During the first aid phase, the person should be moved away from cold, windy, and wet conditions to a warm and dry area. In the first aid and medical intervention processes for hypothermia, there are two important goals: to prevent further heat loss in the patient and to increase body temperature.

What is Good for Low Blood Pressure? Symptoms of Low Blood Pressure

Blood pressure is an indicator that measures the resistance created by the blood pumped by the heart in the blood vessels. There are two different values for this pressure: systolic and diastolic. Systolic pressure, also known as high blood pressure, measures the blood pressure during the heart's contraction. Diastolic pressure, known as low blood pressure, refers to the measurement of blood pressure during the heart's resting phase. Low blood pressure is a health issue characterized by blood pressure being lower than the normal range. For healthy individuals, the ideal blood pressure is expressed as 120/80. Here, the value of 120 indicates systolic pressure, while the value of 80 refers to diastolic blood pressure. Low blood pressure is characterized by blood pressure values lower than 90/60. In some cases, low blood pressure may indicate a serious health problem. Especially in older individuals, low blood pressure can obstruct sufficient blood flow to the heart, brain, and other vital organs. This can lead to symptoms such as dizziness, fainting, and shock. Causes of low blood pressure may include dehydration, pregnancy, heart disorders, nervous system diseases, and certain medications. To prevent and treat low blood pressure, lifestyle changes such as drinking adequate amounts of water, increasing salt intake, rising slowly from a seated position, avoiding caffeine, eating low-carbohydrate meals, exercising the leg muscles, and wearing compression stockings can be applied. In some cases, medication treatment may also be recommended by a doctor.